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Paeoniflorin Suppresses Rheumatoid Arthritis Development via ...

Paeoniflorin Suppresses Rheumatoid Arthritis Development via ...

Aug 23, 2021 · Paeoniflorin is an active ingredient derived from Paeonia, which has an anti-inflammatory effect. However, the potential role and basis of paeoniflorin in rheuma. Cell viability, cycle distribution, migration, and invasion were evaluated via Cell Counting Kit-8 (CCK-8), flow cytometry, and transwell assays. The contents of inflammatory cytokines were examined ...
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exerts neuroprotective effects against glutamate ...

exerts neuroprotective effects against glutamate ...

Jul 20, 2017 · Paeoniflorin (PF) is an active ingredient of Radix Paeoniae, which is known to exert neuroprotective effects. However, the mechanims behind the neuroprotective effects of PF are not yet fully understood.
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Paeoniflorin improves menopause depression in ovariectomized ...

Paeoniflorin improves menopause depression in ovariectomized ...

Apr 15, 2015 · The effects of paeoniflorin on (A) crossing numbers and (B) rearing numbers in open field test at day14 in the following groups: control, model, FLX and paeoniflorin group. When the hind legs crossed the line of the squares, the rat was considered to have crossed from one square to another (crossing) when the forelegs lift from the floor, the ...
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Paeoniflorin attenuates impairment of spatial learning and ...

Paeoniflorin attenuates impairment of spatial learning and ...

May 21, 2019 · Paeoniflorin treatment had no effect on depression-like behaviors in control mice (control + paeoniflorin vs. control + saline: all p > 0.05, Tukey’s tests Fig. 1). Therefore, paeoniflorin treatment effeceased depression-like behaviors, and paeoniflorin had no effect on depression-like behaviors in control mice.
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Italy vs Switzerland Preview: Probable Lineups, Prediction ...

Italy vs Switzerland Preview: Probable Lineups, Prediction ...

Nov 12, 2021 · Italy and Switzerland are joint top in the group, with both teams having collected 14 points each from six games. With just the table-toppers guaranteed spot and the …
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through reducing ...

through reducing ...

Apr 03, 2020 · Paeoniflorin is a natural monoterpene glucoside from Paeoniae Radix with neuroprotective properties. However, it is still unclear whether paeoniflorin has neuroprotective effects on subarachnoid hemorrhage (SAH). This study explores the effect of paeoniflorin on early brain injury (EBI) using rat SAH model. We found that paeoniflorin significantly improves neurological deficits, attenuates ...
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Paeoniflorin Suppressed High Glucose-Induced Retinal ...

Paeoniflorin Suppressed High Glucose-Induced Retinal ...

Jun 21, 2017 · Paeoniflorin suppressed STZ-induced IBA-1 and IL-1β expression and decreased STZ-induced high blood glucose level. In conclusion, paeoniflorin suppressed high glucose-induced retinal microglia MMP-9 expression and inflammatory response via inhibition of the TLR4/NF-κB pathway through upregulation of SOCS3 in diabetic retinopathy.
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inhibits PDGF‑BB‑induced human airway smooth ...

inhibits PDGF‑BB‑induced human airway smooth ...

sion of asthma. Paeoniflorin (PF), one of the major active ingredients of Paeonia lactiflora, has been reported to exhibit anti-asthmatic effects. However, the effects of PF in the regu-lation of platelet-derived growth factor (PDGF)-BB-induced ASMC proliferation and migration remain unknown. The
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Evaluating the Therapeutic Mechanisms of Selected Active ...

Evaluating the Therapeutic Mechanisms of Selected Active ...

Apr 21, 2021 · The isomers paeoniflorin and albiflorin have shown, in addition to their anti-inflammatory activities (Wang et al., 2014), therapeutic effectiveness against neuropathic pain (Zhou et al., 2016) and bone marrow suppression (Zhu et al., 2016). Given this, the effect of Cornus officinalis and Paeonia lactiflora on RA and the molecular mechanisms ...
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Influence of food on the pharmacokinetics of oral ...

Influence of food on the pharmacokinetics of oral ...

The delaying effect of food on t max was less marked (median of 3.0 vs. 2.0 h). eased exposure to drug metabolites. Variability in exposure was markedly reduced if alitretinoin was taken with vs. without food (percentage coefficient of variation 40% vs. 74% for AUC 49% vs. 85% for C max). Alitretinoin was ...
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MSN

MSN

Nov 12, 2021 · MSN
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Paeoniflorin ≥98% (HPLC) |-6

Paeoniflorin ≥98% (HPLC) |-6

Molecules (Basel, Switzerland), 17(8), -28) ... Paeoniflorin has been demonstrated to exert anti-inflammatory and immunomodulatory effects in the ...
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Comparative transcri ...

Comparative transcri ...

The herbaceous peony (Paeonia lactiflora Pall.) is a perennial flowering plant of the Paeoniaceae species that is widely cultivated for medical and ornamental uses. The monoterpene glucoside paeoniflorin and its derivatives are the active compounds of the P. lactiflora roots. However, the gene regulation pathways associated with monoterpene and paeoniflorin biosynthesis in P. lactiflora are ...
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Ameliorates Atherosclerosis by Suppressing TLR4 ...

Ameliorates Atherosclerosis by Suppressing TLR4 ...

Aug 08, 2017 · Paeoniflorin, a type of bioactive monoterpene glucoside in Paeoniae Radix, possesses anti-oxidative, anti-inflammatory and anti-hyperglycaemic properties. However, the underlying mechanism of paeoniflorin in treating atherosclerosis is unclear. A rat model of high-fat diet-induced atherosclerosis and palmitic acid (PA)-treated vascular smooth muscle cells (VSMCs) were used in this study. The ...
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Nutrients | Free Full-Text | Paeoniflorin Ameliorates ...

Nutrients | Free Full-Text | Paeoniflorin Ameliorates ...

The present study aimed to evaluate the effects of paeoniflorin on insulin resistance and hepatic steatosis induced by fructose. Male Sprague-Dawley rats were fed 20% fructose drink for eight weeks. The insulin sensitivity, serum lipid profiles, and hepatic lipids contents were measured. The results showed that paeoniflorin significantly decreased serum insulin and glucagon levels, improved ...
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The Traditional Medicine and Modern Medicine from Natural ...

The Traditional Medicine and Modern Medicine from Natural ...

Apr 29, 2016 · Natural products and traditional medicines are of great importance. Such forms of medicine as traditional Chinese medicine, Ayurveda, Kampo, traditional Korean medicine, and Ui have been practiced in some areas of the world and have blossomed into …
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Frontiers | The Regulatory Effects of Paeoniflorin and Its ...

Frontiers | The Regulatory Effects of Paeoniflorin and Its ...

The Developmental Process of TGP-Pae-CP-25 The glycoside mixture TGP is an active plant extract that is isolated from the roots of Paeonia lactiflora Pall, a traditional Chinese medicine (TCM). In 1998, TGP was approved by the National Medical Products Administration (NMPA) for anti-inflammatory and immunomodulatory therapy in China. It has been used in the treatment of Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) (Chen et al., 2013 Wang et al., 2014). Meanwhile a series of further studies has demonstrated that TG... See full list on Arthritis The anti-inflammatory and immunoregulatory effects of Pae on mesenteric lymph node (MLN) lymphocytes and the underlying mechanisms were investigated in an adjuvant arthritis (AA) rat model. Pae greatly reduced arthritis scores and secondary hind paw swelling, pro-inflammatory cytokine production and the proliferation of MLN lymphocytes. Pae induced the expression of β2-adrenergic receptor (ADRB2) and decreased that of β-arrestin1/2 in MLN lymphocytes. In addition, Pae reversed the pro-inflamm... Liver Diseases Pae treatment showed protective effect for several liver diseases. Ma et al. (2016) demonstrated that the Pae repressed serum alanine transferase (ALT), aspartate transferase (AST) and total levels of cholesterol (TC), low-density lipoprotein (LDL), and TNF-α, from a non-alcoholic steatohepatitis (NASH) rat model via inhibiting Rho kinase (ROCK) and NF-κB pathway. Zhao et al. (Zhao et al., 2017) evaluated the effect of Pae on α-naphthylisothiocyanate (ANIT)-induced cholestasis rat model. Pae... Kidney Diseases High glucose activated macrophages mainly through TLR2-dependent pathway which aggravated the severity of renal inflammation and eventually contributed to diabetic nephropathy (DN). Pae might be used as a potential therapeutic agent against progressive DN (Shao et al., 2016). In vivo, Pae reduced the urinary albumin excretion rate and inhibit macrophage infiltration and activation through inhibition of the TLR2/4 pathway. In vitro, Pae reduced the advanced glycation end products (AGEs)-induce... See full list on Recombit human interleukin-1b (rhIL-1β) was used to treat primary monocytes to imitate inflammatory condition in vitro. Pae showed low cytotoxi on rhIL-1β-treated monocytes. Pae significantly suppressed phagocytic function of rhIL-1β-induced monocytes, and decreased the levels of TNF-α and PGE2 production. Administration of Pae significantly inhibited the HLA-DR and CD80 with rhIL-1β-stimulated monocytes. These results indicated that Pae could inhibit activation and normal function of monocytes in human peripheral blood (Wang D. et al., 2012). Another similar study focused on the effect of Pae on rhIL-1β-stimulated human peripheral blood mononuclear cells (PBMCs). Pae inhibited the proliferation of rhIL-1β-treated PBMCs and production of IL-17 and IL-10. rhIL-1β-induced down-regulation of PBMCs CD4+CD25+Foxp3+ subpopulation numbers was also repressed by Pae. Therefore, Pae exerts its anti-inflammatory effects via regulating IL-17/IL-10 secretion (Dai et al., 2015). Topical ap... See full list on Arthritis By using a T cell and FLS co-culture system, CP-25 repressed the proliferation and production of pro-inflammatory cytokines of FLS via inhibiting BAFF-R in CD4+ T cells, suggesting that CP-25 could interfere in the crosstalk between T cells and FLS in vitro (Jia et al., 2016). The AA model was used to investigate the anti-arthritic activity of CP-25. In general, CP-25 repressed both the clinical and the histopathological scores of arthritis. The levels ouding... Other Chronic Inflammatory Diseases Bone marrow dendritic cells (DCs) were isolated from BALB/c mice and stimulated by PGE2 and TNF-α, respectively, which induced CD40, CD80, CD83, CD86, and MHC-II and suppressed the antigen uptake by DCs. Additionally, the proliferation of T cells was induced using a co-culture system. The expression of surface markers, DC antigen uptake and DC-mediated proliferation of T cells were inhibited by CP-25 treatment. Moreover, CP-25 decreased PGE2-induced EP4 and NF-κB and induced PGE2-suppressed i... Absorption and Excretion As a bioavailable derivative of Pae, CP-25 improves the absorption of Pae. This has been attributed to both the lipid solubility enhancement and its resistance to P-gp-mediated efflux (Yang et al., 2016). With regard to tissue distribution, CP-25 concentration was higher in most tissues when compared to Pae via an oral route with the highest concentration in the liver at 3 h after ouding intestine, synovium, muscle, lung, and brain in both male and female rat... See full list on The mixture of glycosides Pae has been shown to be anti-inflammatory, anti-neoplastic, anti-hyperglycemia, and neuroprotective. To improve oral bioavailability of Pae. Paeoniflorin-6′-O-benzene sulfonate (CP-25) was developed which enhanced eases could be shown in animal experiments. Current basic and preclinical studies imply that these natural compounds with their strong anti-inflammatory properties should be considered in the clinic. As shown in various preclinical studies, Pae and its derivative CP-25 demonstrated positive effects on chronic inflammatory diseases, such as arthritis, and in different models of liver injury and kidney injury. The use in therapy modulated inflammatory mediators such as cytokines (IL-1β, IL-6, TNF-α), chemokines (CCL8), pattern recognition receptors and their relevant transcription factors (STAT, NF-κB). Although the effectiveness of Pae and CP-25 has been demonstrated, aspects such as pharmacokinetics and product s... See full list on This study was supported by the National Natural Science Foundation of China and), Natural Sc for Young Scholars (1708085QH200), and Grants for Scientific Research of BSKY from Medical University ). See full list on The authors declare that the research was conducted in the absence of any commercial or ficial relationships that could be construed as a potential conflict of interest. See full list on
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Generic Cialis Online is popular ED treatment

Generic Cialis Online is popular ED treatment

A question we hear a lot is, “H ow long does it take to become a pharmacist?” To practice pharmacy in the U.S., you must earn a Doctor of Pharmacy (PharmD) degree from an accredited pharmacy institution and pass a state pharmacy licensure exam. U.S. pharmacy institutions are accredited by the Accreditation Council for Pharmacy Education (ACPE).
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Pharmacokinetic Comparison of Scutellarin and Paeoniflorin ...

Pharmacokinetic Comparison of Scutellarin and Paeoniflorin ...

Xin-Shao formula is a folk remedy widely used in China to prevent and cure stroke. Cerebral ischemic reperfusion (I/R) injury often takes place during the treatment of stroke. Information about the pharmacokinetic behavior of the remedy under cerebral I/R injury conditions is lacking. The present study aimed to compare the pharmacokinetic properties of scutellarin and paeoniflorin, two major ...
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IJMS | Free Full-Text | Experimental Models, Induction ...

IJMS | Free Full-Text | Experimental Models, Induction ...

Nov 09, 2021 · Dry eye disease (DED) is one of the major ophthalmological healthcare challenges worldwide. DED is a multifactorial disease characterized by a loss of homeostasis of the tear film, and its main pathogenesis is chronic ocular surface inflammation related with various cellular and molecular signaling cascades. The animal model is a reliable and effective tool for understanding the various ...
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Paeoniflorin Ameliorates Atherosclerosis by Suppressing ...

Paeoniflorin Ameliorates Atherosclerosis by Suppressing ...

Aug 08, 2017 · Paeoniflorin, a type of bioactive monoterpene glucoside in Paeoniae Radix, possesses anti-oxidative, anti-inflammatory and anti-hyperglycaemic properties. However, the underlying mechanism of paeoniflorin in treating atherosclerosis is unclear. A rat model of high-fat diet-induced atherosclerosis and palmitic acid (PA)-treated vascular smooth muscle cells (VSMCs) were used in this study. The ...
Get Price