better Paeoniflorin Russia

Jun 14, 2021 · Liapina LA, Ammosova IaM, Novikov VS, et al. [The nature of an anticoagulant isolated from peonies in the central zone of Russia]. Izv Akad Nauk Ser Biol 1997. . View abstract. Liu C, Wang J, Yang J. [Study on activating blood and eliminating stasis of total paeony glycoside(TPG)]. Zhong Yao Cai 2000. . View abstract.

Nov 21, 2021 · 38,420 new cases and 1,211 new deaths in Russia [ source] November 14. Updates. 38,823 new cases and 1,219 new deaths in Russia [ source] November 13. Updates. 39,256 new cases and 1,241 new deaths in Russia [ source] November 12. Updates.

The objective of this systematic review was to conduct a meta-analysis of the efficacy and safety of total glucosides of paeony (TGP) for the treatment of ankylosing spondylitis (AS). TGP is commonly applied as a complementary medicine, especially in combination with disease-modifying antirheumatic drugs (DMARDs) and/or non-steroidal anti-inflammatory drugs (NSAIDs) to treat AS in China ...

Aug 10, 2021 · Liapina LA, Ammosova IaM, Novikov VS, et al. [The nature of an anticoagulant isolated from peonies in the central zone of Russia]. Izv Akad Nauk Ser Biol. 1997 Mar-Apr (2). https:///9190224/

Jun 11, 2021 · Liapina LA, Ammosova IaM, Novikov VS, et al. [The nature of an anticoagulant isolated from peonies in the central zone of Russia]. Izv Akad Nauk Ser Biol 1997. . View abstract. Liu C, Wang J, Yang J. [Study on activating blood and eliminating stasis of total paeony glycoside(TPG)]. Zhong Yao Cai 2000. . View abstract.

Sep 14, 2021 · Paeonia lactiflora May Help Regulate Anti-Inflammatory Effects, Study Reveals. The 2020 Journal of Ethnopharmacology study shows that the plant may prove effective in the treatment of autoimmune ...

Nov 20, 2021 · House approves Biden’s $2 trillion ‘Build Back Better Plan’. 20 Nov, 2021 07:07. More. The Build Back Better package is now headed to the Senate after the House passed the nearly $2 trillion bill – which is a key piece of President Joe Biden’s economic agenda. We’ll break down the numbers and discuss what this could mean for the ...

Nov 05, 2021 · A Russian analyst who contributed to a dossier of Democratic-funded research into ties between Russia and Donald Trump was indicted Thursday on charges of lying to the FBI about his sources of ...

Nov 14, 2021 · The risk of an accidental war breaking out between Russia and the West is greater than at any time during the Cold War, Britain's most senior military officer has said in an interview with Times ...

Sep 30, 2021 · Paeoniflorin Market Segment by Regions, Regional Analysis Covers: North America (United States, Canada and Mexico) Europe (Germany, France, UK, Russia and Italy)

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Ulcerative colitis (UC) is a common refractory and life-long disease (Sedghi, 2016 Murakami et al., 2018). Tude gastroenteritis, fever, diarrhea, rectal bleeding, mucus in stools, sense of urgency for bowel movements, and abdominal pain (Xu et al., 2016). The occasional eude arthritis, iridocyclitis, episcleritis, erythema nodosum, liver dysfunction, and skin lesions. The etiology of UC remains unknown. Modern researchers believe that the etiology involves genetic factors, environmental factors, microbial infections, and other factors (Dulai and Jairath, 2018). Some researchers consider UC to be an autoimmune disease (Wiese et al., 2016 Kim et al., 2017). Currently, UC cannot be completely cured and life-long treatment is needed in most cases (Nowarski et al., 2015). Further, 20–30% of patients with severe UC require surgery as a part of their treatment (Lanzoni et al., 2008). Anti-inflammatory treatment with drug... See full list on Materials and Reagents Baicalin (CAS number-9), baicalein (CAS number), and sodium hydroxymethylcellulose (CMC-Na CAS number-1) . Pentabarbital (CAS number), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (GGT), superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), triglyceride (TG), cyclic guanosine monophosphate (cGMP), cyclic adenosine monophosphate (cAMP), sodium-potassium adenos... Preparation of Drug Suspension Solution Baicalin, baicalein, and sulfasalazine were diluted in CMC-Na and the following suspension solutions were constructed: baicalin (100 mg kg-1), baicalein (100 mg kg-1), young Scutellaria baicalensis with a 4:1 ratio of baicalin to baicalein (YSR 100 mg kg-1), withered Scutellaria baicalensis with a 1:1 ratio of baicalin to baicalein (WSR 100 mg kg-1), and sulfasalazine (100 mg kg-1). Solutions were stored in the dark at 4 °C and were used within 5 days of preparation. The proportional relati... Experimental Animals and Grouping Fifty-six Sprague-Dawley (SD) rats (180–220 g) were housed in an SPF-level laboratory. The room temperature was regulated at 18–25°C with 50 ± 5% humidity. A 12 h light/dark cycle was implemented and the rats were fed a standard diet and given free access to water. Animal welfare was ensured and experimental procedures were performed in accordance with the Guide for the Care and Use of Laboratory Animals (Ministry of Science and Technology of China, 2010). This study was approved by the Anima... See full list on Changes in Clinical Symptoms and Signs Before the experiment, all rats were active and their fur was smooth, white, and clean. Their diets, stools, and urine were all normal. At the beginning of the experiment, the rats in the NC group exhibited no obvious abnormalease in their weights (Yi et al., 2010). In all other groups, during the initial 10 days of feeding a high-sugar and higheased water intake and urination. The urine was yellowish on the fasting days, whi... Temperature Changes in the 48 H After Drug Administration As shown in Figure 3B, within 48 h of the first drug dose, the average body temperature of the NC group fluctuated around 36.6°C. Compared with the NC group, the body temperature of the eased (P < 0.05). The model group reached a maximum temperature of 38.9°C before stabilization of temperature at 38.3°C. Compared with the model group, the average body temperatures of the drug groups were significantly reduced to different degrees (P < 0.01). The results indi... Organ Indices As shown in Table 1, the tissues and organs of the NC group were observed to be normal. The livers, spleens, lungs, and kidneys of the model group and the self-healing group had different degrees of congestion, edema, degeneration, necrosis, and inflammation. The organ indices for each organ in the model group was significantly higher than in the NC group (P < 0.05). The organ indices of the treatment groups were significantly lower than those of the UC group. The rats in the UC group exhibit... See full list on We examined the therapeutic effects and mechanisms of action of baicalin and baicalein in the treatment of UC model rats. We found that the two drugs have significant therapeutic differeneased body temperature, weight loss, inflammation, lipids, and liver disturbances. Further, the findings indicate that there are different mechanisms underlying the effects of each drug on inflammatory cytokines in UC. Our study shows that the basic treatment of intestinal diseases such as UC is through anti-inflammatory pathways. The mechanism of action is likely through regulation of the Th17/Treg balance and control of intestinal bacteria. Baicalin, more than baicalein, inhibits inflammatory factors IL-1β and IL-6 and activates the MAKP and NF-κB signaling pathways to induce IL-17 production. The antibacterial and antiviral effects of baicalin and baicalein underlie the treatment effects of these drugs in UC. In this experiment, YSR treatment was found to be supe... See full list on Scutellaria baicalensis is a herbal medicine traditionally used for the treatment of UC. The main components of Scutellaria baicalensis are baicalin and baicalein. In this study, we tested each component separately and in combination for the treatment of UC. Baicalin, baicalein, and a combination of the two drugs, had significantly different effects on UC. We found that baicalin and baicalein have different advantages in treating UC, and a combination of the two drugs provides more comprehensive treatment specifically, YSR was the most effective treatment. The proportion of baicalin in YSR is higher than the proportion of baicalein, consistent with the natural proportion of baicalin and baicalein in young Scutellaria baicalensis. This study compared the mechanisms of action of baicalin and baicalein based on pharmacodynamic indicators and evaluation of chemical composition using metabolomics techniques, UPLC-MS/MS, and traditional pharmacological indicators. It was found that compa... See full list on The animal study was reviewed and approved by the Animal Ethics Committee and Institutional Animal Care and Use Committee of South-Central University for Nationalities. See full list on SL, XD, YZ, JA, LL, LC, HX and YR participated in the experiments. SL, XD and YR analyzed the data and wrote the paper. YR secured the funding, designed the experiments, and revised the paper. LC, ZM, Y-CC, and YR provided technical guidance. SL, YZ, XD, JA, HX and LL participated in experimental preparation and statistical analysis. All authors read and approved the final manuscript. See full list on This work was supported by National Natural Science Foundation of China grants (No., No. and No), National Major Scientific and Technological Special Project for “Significant New Drugs Development” (No. 2017Z-001), National Key R&D Program of China Natural Science Foundation of China (No. 2015CFB302), and Fundamental Research Funds for the Central Universities “South-Central University for Nationalities” (No. CZP17074). See full list on The authors declare that the research was conducted in the absence of any commercial or ficial relationships that could be construed as a potential conflict of interest. See full list on The Supplementary Material for this article can be found online at: https:///articles/10.3389/fphar.2019.01466/full#supplementary-material See full list on

Oct 21, 2021 · Key Points. Russian President Vladimir Putin announced Wednesday that Russians will take a paid week off work in order to try to combat the Covid-19 crisis in the country, as the number of daily ...

Paeoniflorin. Paeoniflorin also demonstrated inhibition of twitch responses in skeletal muscles, an effect that was potentiated in vitro and in vivo by the addition of glycyrrhizin from licorice.160 Additionally, clinical trials have demonstrated positive results in the treatment of dysmenorrhea owing to “qi and blood stasis” (with licorice root), a reduction serum and free testosterone in ...

Aug 07, 2020 · Brazil is now the new hotspot for SARS CoV-2 after the USA, Russia, France, Italy, Germany, Spain, and the UK, where more than 11 million people are infected (166, 167). The pleomorphic or spherical shaped SARS COV-2 has a single-stranded RNA genome of 26.4–31.7 kb in length and a crown-like glycoproteins on its surface ( 168 – 173 ).

White peony root contains paeoniflorin which has been shown in multiple studies to decrease pain, muscle spasm, neuropathic pain, and inflammation. According to traditional Chinese medicine, the Liver controls the free flow of Qi throughout the body. Where Qi goes, Blood goes. Pain is caused by Qi and Blood stagnation.

Apple trees grow well in cool, dry temperate regions. They are mainly distributed in the Loess Plateau, Bohai Bay, Yellow River and Southwest Plateau. China is the world’s largest producer and consumer of apple. Overseas countries such as the United States, Turkey, Italy, France, Poland, Germany and Russia also have large areas of apple trees.

Aug 01, 2021 · * Paeoniflorin compound has recently been proven effective for Rheumatoid Arthritis * Promotes blood circulation - treats hypertension, lowers cholesterol, inhibits blood clotting * Anti-inflammatory - reduces swelling, relieves painful menstruation and headaches, reduces fever * Anti-spasmodic - treats chest pains, muscle cramping and spasms

Introduction: Ulcerative colitis (UC) is an inflammatdence rate and a difficult treatment regimen. Recently, significant advances in the treatment of intestinal diseases, particularly UC, have been made with the use of the drugs baicalin and baicalein, separately or in combination. However, the therapeutic efficacy and mechanism of action of baicalin ...

Nov 20, 2021 · House approves Biden’s $2 trillion ‘Build Back Better Plan’. 20 Nov, 2021 07:07. More. The Build Back Better package is now headed to the Senate after the House passed the nearly $2 trillion bill – which is a key piece of President Joe Biden’s economic agenda. We’ll break down the numbers and discuss what this could mean for the ...

Nov 11, 2021 · The U.S. is raising the m with European Union allies that Russia may be weighing a potential invasion of Ukraine as tensions flare between Moscow and the bloc over migrants and energy supplies.

The Developmental Process of TGP-Pae-CP-25 The glycoside mixture TGP is an active plant extract that is isolated from the roots of Paeonia lactiflora Pall, a traditional Chinese medicine (TCM). In 1998, TGP was approved by the National Medical Products Administration (NMPA) for anti-inflammatory and immunomodulatory therapy in China. It has been used in the treatment of Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) (Chen et al., 2013 Wang et al., 2014). Meanwhile a series of further studies has demonstrated that TG... See full list on Arthritis The anti-inflammatory and immunoregulatory effects of Pae on mesenteric lymph node (MLN) lymphocytes and the underlying mechanisms were investigated in an adjuvant arthritis (AA) rat model. Pae greatly reduced arthritis scores and secondary hind paw swelling, pro-inflammatory cytokine production and the proliferation of MLN lymphocytes. Pae induced the expression of β2-adrenergic receptor (ADRB2) and decreased that of β-arrestin1/2 in MLN lymphocytes. In addition, Pae reversed the pro-inflamm... Liver Diseases Pae treatment showed protective effect for several liver diseases. Ma et al. (2016) demonstrated that the Pae repressed serum alanine transferase (ALT), aspartate transferase (AST) and total levels of cholesterol (TC), low-density lipoprotein (LDL), and TNF-α, from a non-alcoholic steatohepatitis (NASH) rat model via inhibiting Rho kinase (ROCK) and NF-κB pathway. Zhao et al. (Zhao et al., 2017) evaluated the effect of Pae on α-naphthylisothiocyanate (ANIT)-induced cholestasis rat model. Pae... Kidney Diseases High glucose activated macrophages mainly through TLR2-dependent pathway which aggravated the severity of renal inflammation and eventually contributed to diabetic nephropathy (DN). Pae might be used as a potential therapeutic agent against progressive DN (Shao et al., 2016). In vivo, Pae reduced the urinary albumin excretion rate and inhibit macrophage infiltration and activation through inhibition of the TLR2/4 pathway. In vitro, Pae reduced the advanced glycation end products (AGEs)-induce... See full list on Recombit human interleukin-1b (rhIL-1β) was used to treat primary monocytes to imitate inflammatory condition in vitro. Pae showed low cytotoxi on rhIL-1β-treated monocytes. Pae significantly suppressed phagocytic function of rhIL-1β-induced monocytes, and decreased the levels of TNF-α and PGE2 production. Administration of Pae significantly inhibited the HLA-DR and CD80 with rhIL-1β-stimulated monocytes. These results indicated that Pae could inhibit activation and normal function of monocytes in human peripheral blood (Wang D. et al., 2012). Another similar study focused on the effect of Pae on rhIL-1β-stimulated human peripheral blood mononuclear cells (PBMCs). Pae inhibited the proliferation of rhIL-1β-treated PBMCs and production of IL-17 and IL-10. rhIL-1β-induced down-regulation of PBMCs CD4+CD25+Foxp3+ subpopulation numbers was also repressed by Pae. Therefore, Pae exerts its anti-inflammatory effects via regulating IL-17/IL-10 secretion (Dai et al., 2015). Topical ap... See full list on Arthritis By using a T cell and FLS co-culture system, CP-25 repressed the proliferation and production of pro-inflammatory cytokines of FLS via inhibiting BAFF-R in CD4+ T cells, suggesting that CP-25 could interfere in the crosstalk between T cells and FLS in vitro (Jia et al., 2016). The AA model was used to investigate the anti-arthritic activity of CP-25. In general, CP-25 repressed both the clinical and the histopathological scores of arthritis. The levels ouding... Other Chronic Inflammatory Diseases Bone marrow dendritic cells (DCs) were isolated from BALB/c mice and stimulated by PGE2 and TNF-α, respectively, which induced CD40, CD80, CD83, CD86, and MHC-II and suppressed the antigen uptake by DCs. Additionally, the proliferation of T cells was induced using a co-culture system. The expression of surface markers, DC antigen uptake and DC-mediated proliferation of T cells were inhibited by CP-25 treatment. Moreover, CP-25 decreased PGE2-induced EP4 and NF-κB and induced PGE2-suppressed i... Absorption and Excretion As a bioavailable derivative of Pae, CP-25 improves the absorption of Pae. This has been attributed to both the lipid solubility enhancement and its resistance to P-gp-mediated efflux (Yang et al., 2016). With regard to tissue distribution, CP-25 concentration was higher in most tissues when compared to Pae via an oral route with the highest concentration in the liver at 3 h after ouding intestine, synovium, muscle, lung, and brain in both male and female rat... See full list on The mixture of glycosides Pae has been shown to be anti-inflammatory, anti-neoplastic, anti-hyperglycemia, and neuroprotective. To improve oral bioavailability of Pae. Paeoniflorin-6′-O-benzene sulfonate (CP-25) was developed which enhanced eases could be shown in animal experiments. Current basic and preclinical studies imply that these natural compounds with their strong anti-inflammatory properties should be considered in the clinic. As shown in various preclinical studies, Pae and its derivative CP-25 demonstrated positive effects on chronic inflammatory diseases, such as arthritis, and in different models of liver injury and kidney injury. The use in therapy modulated inflammatory mediators such as cytokines (IL-1β, IL-6, TNF-α), chemokines (CCL8), pattern recognition receptors and their relevant transcription factors (STAT, NF-κB). Although the effectiveness of Pae and CP-25 has been demonstrated, aspects such as pharmacokinetics and product s... See full list on This study was supported by the National Natural Science Foundation of China and), Natural Sc for Young Scholars (1708085QH200), and Grants for Scientific Research of BSKY from Medical University ). See full list on The authors declare that the research was conducted in the absence of any commercial or ficial relationships that could be construed as a potential conflict of interest. See full list on

Apr 29, 2016 · Russia. 10th century. Due to the special geographical environment of Russia, Russian herbal therapy has collected and adopted traditional medicine methods that were introduced from Europe and Asia. The Russian Federation follows the State Pharmacopoeia of the USSR 32 of 83 individual plant monographs are found only in this Pharmacopoeia.

Plant Source of Peony Root Extract: The peony or paeony is a flowering plant in the genus Paeonia, the only genus in the family Paeoniaceae. They are native to Asia, Europe and Western North America. Scientists differ on the number of species that can be distinguished ranging from 25 to 40, although the current consensus is 33 known species.

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Figure 16. Paeoniflorin Production Share by Manufacturers in 2020 Figure 17. Global Paeoniflorin Revenue Share by Manufacturers in 2020 Figure 18. Type (Tier 1, Tier 2 and Tier 3): 2016 VS 2020 Figure 19. Global Market Paeoniflorin Average Price (K USD/Kg) of Key Manufacturers in 2020 Figure 20.

Sep 30, 2021 · Paeoniflorin Market Segment by Regions, Regional Analysis Covers: North America (United States, Canada and Mexico) Europe (Germany, France, UK, Russia and Italy)

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation.

Peony is a plant. The root and, less commonly, the flower and seed are used to make medicine. Peony is sometimes called red peony and white peony.

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Paeoniflorin is a monoterpene glycoside first isolated from the roots of peony. It uding modulating NMDA and TRPV1 receptors. 1,2 Paeoniflorin is reported to inhibit testosterone synthesis and stimulate aromatase activity. 3 It also reduces inflammatory signaling by inhibiting p38 MAP kinase and blocks pancreatic cancer cell apoptosis by suppressing MMP-9 and ...