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Cost-effective Artemisinin Albania

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Artemisia annua L. hot-water extracts show potent activity in ...

Artemisia annua L. hot-water extracts show potent activity in ...

Results: In addition to being effective against the original wild type (WT) WA1, A. annua cultivars A3, BUR, MED, and SAM were also potent against all five variants. IC 50 and IC 90 values based on measured artemisinin content ranged from 0.3 to 8.4 μM and 1.4-25.0 μM, respectively.
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in planta can improve ...

in planta can improve ...

Apr 14, 2020 · Artemisinin, an effective antimalarial drug, is recommended by the World Health Organization to treat uncomplicated malaria since 2012 . However, due to the unstable availability of its natural source, A. annua , the supply and price of artemisinin fluctuated dramatically ( 37 ).
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Cost-effectiveness of artemisinin-naphthoquine versus ...

Cost-effectiveness of artemisinin-naphthoquine versus ...

An indicative extrapolation estimated the cost per life year saved by using AN instead of AL to treat uncomplicated malaria to be $12,165 for girls and $12,469 for boys … Cost-effectiveness of artemisinin-naphthoquine versus artemether-lumefantrine for the treatment of uncomplicated malaria in Papua New Guinean children
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The Long View: Headless puppies, fishing nets, and G&Ts ...

The Long View: Headless puppies, fishing nets, and G&Ts ...

Oct 07, 2021 · Artemisinin, used against falciparum infections, is derived from sweet wormwood, which was recommended in the treatment of chills and fevers in China nearly 2,000 years ago. Long before people knew why or how it worked – those discoveries were only made in the mid-1970s – people knew that it did.
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Zacks Small Cap Research - MATN: Positive Interim Results for ...

Zacks Small Cap Research - MATN: Positive Interim Results for ...

Jan 14, 2021 · Artemisinin is one of the active components of ArtiShield and is known to inhibit the TGF-β signaling pathway and neutralize SARS-CoV-2 in vitro at a concentration of 0.45 μg/mL while exhibiting a safety index of 140, which is better than remdesivir and chloroquine.
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Artemisia annua L. extracts prevent in vitro replication of ...

Artemisia annua L. extracts prevent in vitro replication of ...

Jan 08, 2021 · Results suggest the active component in the extracts is likely something besides artemisinin or is a combination of components acting synergistically to block post-entry viral infection. Further studies will determine in vivo efficacy to assess whether A. annua might provide a cost-effective therapeutic to treat SARS-CoV-2 infections.
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Malaria vaccine: Can  RTS,S ...

Malaria vaccine: Can RTS,S ...

Apr 23, 2021 · The second pillar in the fight against malaria is a drug called artemisinin. Discovered in 1972, it is generally given as part of a cocktail of drugs known as artemisinin-based combination ...
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WHO/HAI Project on Medicine Prices and Availability

WHO/HAI Project on Medicine Prices and Availability

external reference pricing, mark-up regulation, pharmacoeconomics and cost-plus pricing) and other related issues including the role of health insurance in the cost-effective use of medicines, encouraging competition, and sales taxes on medicines. The reviews are not meant to recommend
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Commercial Production of Semi-Synthetic  – All ...

Commercial Production of Semi-Synthetic – All ...

Aug 07, 2016 · Synthetic Biology and the Development of Commercial β-Farnesene Production Strains Semi-synthetic artemisinin is a pharmaceutical with a price point comparable to plant-derived artemisinin,20 namely above $150 per kg. β-Farnesene, however, is a specialty chemical with multiple uses (more details below); most specialty and commodity chemicals ...
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Analyte ...

Analyte ...

Mar 14, 2013 · Therefore, it is the need of the hour to develop an effective and low-cost drug to cure malaria. Artemisinin (Figure 1 ), a sesquiterpene lactone with an endoperoxide bridge, which is rare in secondary metabolites, is isolated from Artemisia annua L. Artemisinin is responsible for the therapeutic effects of the plant.
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Where to buy Artemisinin manufacturer &suppliers

Where to buy Artemisinin manufacturer &suppliers

Artemisinin. $425.00/KG. Specification: Test by : HPLC. 99%. Quantity: KG G. Sign in to send inquiry. Follow us to get newest specification, price and information about Artemisinin.
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Artemisia annua hot-water extracts show potent activity in ...

Artemisia annua hot-water extracts show potent activity in ...

Sep 08, 2021 · In addition to being effective against the original wild type WA1, A. annua. cultivars A3, BUR, MED and SAM were also potent against all five variants. IC. 50. and IC. 90. values based on measured artemisinin content ranged from 0.3-8.4 µM and 1.4-25.0 µM, respectively. The IC. 50. and IC. 90
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Artemisia annua hot-water extracts show potent activity in ...

Artemisia annua hot-water extracts show potent activity in ...

Sep 08, 2021 · Results In addition to being effective against the original wild type WA1, A. annua cultivars A3, BUR, MED and SAM were also potent against all five variants. IC 50 and IC 90 values based on measured artemisinin content ranged from 0.3-8.4 μM and 1.4-25.0 μM, respectively.
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-effectiveness of malaria diagnostic methods in sub ...

-effectiveness of malaria diagnostic methods in sub ...

cost of the test; diagnosis according to presumptive treatment was assumed to cost nothing. We assumed drug cost per adult dose to be US$ 1–2.4 for ACT and US$ 0.61–0.93 for antibiotics. We set the cost of RDT kits at US$ 0.6–1 and that of microscopy at US$ 0.32–1.27. Microscopy costs are depen-dent on workload and were based on a
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Early Research Finds Extracts from Sweet Wormwood Plant Can ...

Early Research Finds Extracts from Sweet Wormwood Plant Can ...

May 04, 2021 · “A. annua could provide clues to new safe, cost-effective small molecule therapies or even be used as an antiviral nutraceutical.” The researchers soaked dried leaves of A. annua, obtained from four continents in hot water and tested the solutions against SARS-CoV-2 and two variants originating from the United Kingdom and South Africa. Some ...
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Artemisinin-based combination therapies (ACTs): Best hope ...

Artemisinin-based combination therapies (ACTs): Best hope ...

Artemisinin enhances efficacy and has the potential of lowering the rate at which resistance emerges and spreads. Under low transmission intensity, ACTs have an additional public health benefit of reducing the overall malaria transmission and studies are urgently needed to investigate modalities of attaining similar benefits under high ...
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PRODUCTION AND PRICINGEarly Research Finds Extracts from Sweet Wormwood Plant ...Artemisia annua L. extracts prevent in vitro replication ...

PRODUCTION AND PRICINGEarly Research Finds Extracts from Sweet Wormwood Plant ...Artemisia annua L. extracts prevent in vitro replication ...

People also askWhat was the price of artemisinin in 2011? See all results for this questionWhat kind of research is being done on Artemisia? See all results for this questionWhat is the IC 50 of Artemisia annua L? See all results for this question
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A THRESHOLD ANALYSIS OF THE -EFFECTIVENESS OF  ...

A THRESHOLD ANALYSIS OF THE -EFFECTIVENESS OF ...

A THRESHOLD ANALYSIS OF THE COST-EFFECTIVENESS OF ARTEMISININ-BASED COMBINATION THERAPIES IN SUB-SAHARAN AFRICA. 2004. Samuel Shillcutt. Download PDF. Download Full ...
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Production of the antimalarial drug precursor artemisinic ...

Production of the antimalarial drug precursor artemisinic ...

Apr 13, 2006 · Artemisinin, a sesquiterpene lactone endoperoxide extracted from Artemisia annua L (family Asteraceae; commonly known as sweet wormwood), is highly effective against multi-drug-resistant ...
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ARTEMISININ PRODUCTION AND PRICING - MMV

ARTEMISININ PRODUCTION AND PRICING - MMV

Artemisin production cost (2) Cost of leaves: from 400 $/T for wild to 800 $/T. Extraction cost: about 200 $/T of leaves Purification cost: about 600 $/T of leaves for chromatography. Efficiency 70% in that case. Content in the leaves is the key point.
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combat malaria ...

combat malaria ...

Dec 01, 2005 · In Afr-D, case management with artemisinin based combination treatments at 80% target coverage is the most cost effective intervention overall and would be the first choice where resources are limited, whereas a target coverage of 95% is needed in Afr-E.
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news and latest updates

news and latest updates

Students from Trinity College Dublin have successfully created anti-malarial 'biobricks', which could pave the way for easier and more cost-effective production of the key drug artemisinin. Nov 02 ...
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Signs NATO Letter of Intent on Chemical, Biological ...

Signs NATO Letter of Intent on Chemical, Biological ...

Oct 23, 2021 · Albania, along with 10 other NATO Allies has signed a letter of intent to provide protection and support relating to chemical, biological, radiological, and nuclear (CBRN) defence, during the alliance’s meeting on Thursday. The CBRN Protection Equipment will establish a framework for the provision of individual equipment and collective protection systems. Participating countries, including ...
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| U.S. Agency for International Development

| U.S. Agency for International Development

Feb 09, 2021 · The Global Health Supply Chain - Procurement and Supply Management (GHSC-PSM) activity supports the Thai and Laotian Ministries of Health and malaria partners in the procurement, supply chain management, and monitoring and reporting of malaria commodities, such as long-lasting insecticide treated nets, artemisinin-based combination therapies, and malaria rapid diagnostic tests.
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–

Notable enabling technologies developed for routine usage include rapid and reliable assembly of large (i.e., multiple kilobase) deoxyribonucleic acid (DNA) constructs;23-25 high throughput, cost effective, verification of structural DNA assemblies by both initial restriction digest26 and by low-cost DNA sequencing;27 and whole genome ...
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Developing an industrial artemisinic acid fermentation ...

Developing an industrial artemisinic acid fermentation ...

Sep 17, 2008 · The full text of this article hosted at iucr.org is unavailable due to technical difficulties.
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Cost–effectiveness of artemisinin combination therapy for ...

Cost–effectiveness of artemisinin combination therapy for ...

cost per life year saved. Findings A+L proved to be the most effective regimen against . P.alciparum f. malaria and was highly cost-effective at 6.97 United States dollars (US$) per treatment success (about US$ 58 per life year saved). DHA+PQ was the most effective regimen against . P.ivax v. malaria and was more cost-effective than CQ+S+P.
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Evolutionary and Historical Aspects of the Burden of Malaria

Evolutionary and Historical Aspects of the Burden of Malaria

However, having been achieved at such cost, effective immunity is readily lost again. An interval of perhaps half a year to a year without reinfection appears to be sufficient to leave an individual vulnerable, once more, to the full impact of a malarial infection ( 158 , 182 , 186 ; A. Lukas, personal communication).
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Costs and -effectiveness of  control interventions ...

Costs and -effectiveness of control interventions ...

Nov 03, 2011 · Akhavan D, Musgrove P, Abrantes A, Gusmao RD: Cost-effective malaria control in Brazil - Cost-effectiveness of a Malaria Control Program in the Amazon Basin of Brazil, 1988-1996. Soc Sci Med. 1999, 49: 1385-1399. 10.1016/S0277-9536(99)00214-2. CAS Article PubMed Google Scholar 26.
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Artemisia annua L. extracts inhibit the in vitro ...

Artemisia annua L. extracts inhibit the in vitro ...

Artemisia annua is effective in stopping replication of SARS-CoV-2 including 2 new variants.. The anti-viral effect does not correlate to artemisinin, nor to the total flavonoid content. • The anti-viral mechanism does not appear to block virus entry into cell.
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...

...

Sep 17, 2008 · Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies Jacob R. Lenihan , Amyris Biotechnologies, 5980 Horton Street, Suite 450, Emeryville, CA 94608
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Artemisia annua L. extracts inhibit the in vitro replication ...

Artemisia annua L. extracts inhibit the in vitro replication ...

While all hot water extracts were effective, concentrations of artemisinin and total flavonoids varied by nearly 100-fold in the extracts. Artemisinin alone showed an estimated IC 50 of about 70 μM, and the clinically used artemisinin derivatives artesunate, artemether, and dihydroartemisinin were ineffective or cytotoxic at elevated ...
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Artemisia annua L. extracts inhibit the in vitro ...

Artemisia annua L. extracts inhibit the in vitro ...

Ethnopharmacological relevance: Artemisia annua L. has been used for millennia in Southeast Asia to treat "fever". Many infectious microbial and viral diseases have been shown to respond to A. annua and communities around the world use the plant as a medicinal tea, especially for treating malaria.. Aim of the study: SARS-CoV-2 (the cause of Covid-19) globally has infected and killed millions ...
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Bioinspired Microenvironment Responsive Nanoprodrug as an ...

Bioinspired Microenvironment Responsive Nanoprodrug as an ...

Artemisinin compounds have shown satisfactory safety records in anti-malarial clinical practice over decades and have revealed value as inexpensive anti-tumor adjuvant chemotherapeutic drugs. However, the rational design and precise preparation of nanomedicines based on the artemisinin drugs are sti …
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Artemisia annua L. extracts inhibit the in vitro ...

Artemisia annua L. extracts inhibit the in vitro ...

Feb 24, 2021 · Results Hot-water leaf extracts based on artemisinin, total flavonoids, or dry leaf mass showed antiviral activity with IC 50 values of 0.1-8.7 μM, 0.01-0.14 μg, and 23.4-57.4 μg, respectively. Antiviral efficacy did not correlate with artemisinin or total flavonoid contents of the extracts. One dried leaf sample was >12 years old, yet the hot-water extract was still found to be active.
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(PDF) Is chloroquine better than  combination ...

(PDF) Is chloroquine better than combination ...

Is Chloroquine better than Artemisinin combination therapy as first line treatment in adult Nigerians with uncomplicated malaria? a cost effective analysis By Shaibu Bello Cost-effectiveness study of Artemether-lumefantrine, artesunate-amodiaquine and dihydoartemisinin-piperaquine in the treatment of uncomplicated malaria in a nigerian hospital
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The  and -Effectiveness of Antimalarial Drugs ...

The and -Effectiveness of Antimalarial Drugs ...

The new effective drugs— artemisinin combination therapy (ACT) 1 —today cost US$2.40 per course wholesale, and can be marked up to five times that amount in pharmacies in Africa. There are limited alternatives to ACTs for effectiveness and safety for widespread use, and their adoption is recommended by WHO and virtually all other expert bodies.
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Malaria in pregnancy

Malaria in pregnancy

cost-effective interventions for the prevention of the adverse maternal and infant consequences of MiP, the WHO Global Malaria Programme (GMP) convened an ERG with a specific focus on the efficacy of ISTp compared with IPTp, and the safety of artemisinin derivatives in early pregnancy. 2.2 Objectives
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Home - Union Financiar Tirane

Home - Union Financiar Tirane

Union Financiar Tiranë. is the sole agent of Western Union Financial Services Inc. for Albania since 1995. UFT operates in Albania, Kosovo, North Macedonia, Croatia and Switzerland, providing fast, safe and reliable financial services. During 25 years of our experience in Albania we have built the widest network of financial services locations ...
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Developing an  ...

Developing an ...

Developing an industrial artesimic acid fermentation process to support the cost- effective production of anti-malarial artemisinin-based combination therapies (ACTs) September 2008 Biotechnology ...
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Early Research Finds Extracts from Sweet Wormwood Plant ...

Early Research Finds Extracts from Sweet Wormwood Plant ...

May 04, 2021 · “A. annua could provide clues to new safe, cost-effective small molecule therapies or even be used as an antiviral nutraceutical.” The researchers soaked dried leaves of A. annua, obtained from four continents in hot water and tested the solutions against SARS-CoV-2 and two variants originating from the United Kingdom and South Africa. Some ...
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Low-, high-speed identification of counterfeit ...

Low-, high-speed identification of counterfeit ...

Dec 01, 2014 · At a cost of approximately US$ 1–2 per adult treatment, the relatively high priced artesunate drugs have stimulated the growth of counterfeit artesunate production. Such counterfeits contain sub-therapeutic quantities of artesunate or no active drug at all, and have resulted in loss of life due to inadequate treatment of malarial infection [2 ...
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Artemisinin for Cancer, Malaria and More

Artemisinin for Cancer, Malaria and More

Aug 06, 2021 · Artemisinin for Cancer, Malaria and More. Artemisinin has earned some skepticism in past years for its variety of suggested purposes. With its use as an herbicide, some may be slightly wary of using it as an effective herbal remedy; however, the treatment is just that. This pharmaceutical compound has recently earned status as a potent cancer ...
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... | Wellcome Open ...

... | Wellcome Open ...

Apr 07, 2021 · Introduction. In the early 2000s, following widespread development of antimalarial drug resistance to hitherto effective monotherapies, such as chloroquine and sulphadoxine-pyrimethamine (SP), the World Health Organization (WHO) recommended artemisinin-based combination therapies (ACTs) as an approach to improve therapeutic efficacy and delay the development of antimalarial drug resistance ().
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Commercial Production of Semi-Synthetic Artemisinin – All ...

Commercial Production of Semi-Synthetic Artemisinin – All ...

Aug 07, 2016 · Synthetic Biology and the Development of Commercial β-Farnesene Production Strains Semi-synthetic artemisinin is a pharmaceutical with a price point comparable to plant-derived artemisinin,20 namely above $150 per kg. β-Farnesene, however, is a specialty chemical with multiple uses (more details below); most specialty and commodity chemicals ...
Get Price