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Induction of high tolerance to  by sub-lethal ...

Induction of high tolerance to by sub-lethal ...

Jan 17, 2018 · Artemisinin resistance is a major threat to mia control efforts. Resiease in the Plasmodium falciparum parasite clearance half-life following treatment with artemisinin-based combinease in the percentage of surviving parasites. The remarkably short blood half-life of artemisinin derivatives may contribute to drug ...
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Transport of fluoroalkyl dihydroartemisinin derivatives ...

Transport of fluoroalkyl dihydroartemisinin derivatives ...

Artemisinin and its derivatives represent an important class of antimials. In order to obtain new derivatives with a longer half-life and better bioavailability, the development of fluoreasing attention. The purpose of this study was to investigate the permeatio …
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Studies of Potency and Efficacy of an Optimized  ...

Studies of Potency and Efficacy of an Optimized ...

Nov 06, 2021 · A recently developed artemisinin-quinoline hybrid, named 163A, has been shown to display potent activity against the asexual blood stage of Plasmodium, the malaria parasite. In this study, we determined its in vitro cytotoxicity to mammalian cells, its potency to suppress P. berghei hepatic infection and to decrease the viability of P. falciparum gametocytes, in addition to determining whether ...
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NPC Natural Product Communications

NPC Natural Product Communications

1.39% artemisinin, which resulted in a content of 94.5 mg/L artemisinin, administered in five doses of 200 mL each per day. Even if the given dose of artemisinin was only 19% of the usual daily dose of artemisinin in adults [11], peak plasma levels were 240±75ng/mL artemisinin, approximately 40% of the
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The Essential Guide to Over the Counter Medicines in  ...

The Essential Guide to Over the Counter Medicines in ...

‘Farmaci da banco’ is the name for over the counter medicines in Italy those medications you can buy without a doctor’s prescription because they cure minor ailments. Over the counter medicines in Italy can be found in pharmacies, drugstores (parafarmacie) and in the ‘health corners’ of major supermarkets. OTC medicines are displayed on the shelves accessible to …
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Artemisia annua: the opinion of two doctors

Artemisia annua: the opinion of two doctors

Sep 28, 2020 · Hydrolyte (it is a non-alcoholic aqueous extract, or better an herbal tea) Hydroalcoholic extract (it is an alcoholic extract at 65 °) Capsules titrated in Artemisinin (contain 99% Artemisinin) As mentioned, a patient is rarely not recommended to take Artemisia annua.
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Combination Therapy Market Key Country Data 2021 ...

Combination Therapy Market Key Country Data 2021 ...

Artemisinin Combination Therapy Market Key Country Data 2021 | Global Industry Size Based on Current and Future Scenarios, Revenues and Growth with CAGR of 4.8%, Market Dynamics with Impact of Covid-19 till 2027
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Frontiers | Artemisinins as Anticancer Drugs: Novel ...

Frontiers | Artemisinins as Anticancer Drugs: Novel ...

Cancer is becoming a severe health problem internationally and is one of the most deadly diseases (Siegel et al., 2016). Conventional cancer therapy, especially chemotherapy, provides limited efficacy by DNA damage (Li et al., 2017), but has the problems of formidable side effects and drug resistance. To discover novel potent and safe chemotherapeutic agents or seek better curative methods, medicinal chemists, pharmaceutists and pharmacologists have completed many investigations. Artemisinin (ART), bearing a peroxide bridge in its sesquiterpene lactone structure, was extracted and separated from Artemisia annua L. (sweet wormwood), which has been used for treatment of fevers and chills as one of the famous Chinese traditional medicines for thousands of years (Klayman, 1985 Li and Wu, 2003 Cui and Su, 2009 Tu, 2016). ART can be reduced to dihydroartemisinin (DHA) by using sodium borohydride in high yields. Thus, this compound was used as a starting material to prepare the first-ge... See full list on The antitumor activity of ARTs has attracted extensive attention (Firestone and Sundar, 2009 Crespo-Ortiz and Wei, 2012 Frohlich et al., 2016 Wong et al., 2017 Zhang Y. et al., 2ease efficacy and reduce toxi of ARTs, new design strategies for anticancer candidates based on ARTs have been developed. These strategies were raised by researchers from different fields. Medicinal chemists focus more on chemical structural modification to develop novel derivatives whereas pharmacists are more interested in formulation improvement. In our review, we elaborate these novel strategies by focusing on developing novel ART derivatives and manufacturing ART o-formulations as well as combining ARTs with other drugs for cancer therapy. See full list on We searched for clinical trials of ARTs at . and in PubMed. search results by keywords “cancer” and “artesunate” show that some clinical trials of ARS have entered phase II status in recent years. Different modes of administration are used for different cancers. However, no solid final results can be seen yet. In Pubmed, there are only 3 studies in the last 3 years. We summarize the latest research results in 2019 because some previous clinical studies in dogs and humans have been comprehensively reviewed by Efferth and Zhang et al. (Efferth, 2017b Zhang Y. et al., 2018). Recent clinical studies for treating cancer focus on ARS. The results showed dose-limiting toxicities could be seen at dosages of 12, 18 and 25 mg/kg by intravenous ARS in patients with advanced solid tumor maligcies and the maximum tolerated dose was 18 mg/kg using day1/day8, 3-week cycle of administration (Deeken et al., 2018). The adverse events of auditory and vestibular... See full list on ARTs which are already established as safe drugs for treating mia, possess a host of advantages that make them worthy of development as novel anticancer agents. They differ from available anticancer drugs because of the characteristics of high selectivity and effica against multiple cancers in cell and biological models as well as more sensitivity to chemoradiotherapy and less susceptibility to resistance. In this review, we summarized novel cancer therapeutic approaches based on ARTs, the latest molecular mechanisms of action and clinical studies. As a whole, ARTs have great potential to be used in clinical oncology, but there are still many problems to be solved. First, because of poor solubility, short half-life, low bioavailability and toxi of ARTs, developing novel derivatives and odrugs were applied to solve these problems. However, despite the cost savings in drug development by structural modification of ARTs to obtain candidates, updated preclinical and clini... See full list on CX and XY conceived, designed, drafted the manuscript, and amended the paper. HZ designed the figures and tables. LM collected the related research articles. All authors contributed to the article and approved the submitted version. See full list on This work was supported by the Scientific Research Project of Educ (17C0973) to CX and the National Natural Science Foundation of China ) the Key Laboratory of Study and Discovery of Small Ta, Normal University (2017TP1020) and Hug High-Level Talent Innovation Team (2018RS3072) to XY. See full list on The authors declare that the research was conducted in the absence of any commercial or ficial relationships that could be construed as a potential conflict of interest. See full list on Akt, protein kinase B Bak, Bcl-2 homologous antagonist/killer Bcl-2, B cell lymphoma-2 Bax, Bcl-2–associated X protein PI3K, phosphatidylinositol 3-kinase mTOR, mammalian target of rapamycin LC3, light chain 3 CaMKK2, Ca2+/calmodulin-dependent kinase kinase 2 ULK1, unc-51 like autophagy activating kinase 1 PI3KC3, class III phosphatidylinositol 3-kinase T-bet, T-box expressed in T cells MEK, MAPK - mitogen activated protein kinase ERK, extracellular signal-regulated kinase Nrf-2, nuclear factor (erythroid‐derived 2)‐like 2 VEGF, vascular endothelial growth factor JNK, c-Jun-N-terminal kinase γ-H2AX, phosphorylated histone H2AX DSB, double-strand break IFI 16, Interferon-inducible 16 IL, interleukin ATF4, activating transcription factor 4 CHOP, C/EBP homologous protein CHAC1, cation transport regulator-like protein 1 ALDH1, aldehyde dehydrogenase-1. See full list on
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Efficacy and safety of  ...

Efficacy and safety of ...

Nov 26, 2014 · Only one artemisinin combination, namely AS + SP, seems unsuitable for the treatment of vivax mia. Although one non-inferiority trial, from Afghanistan showed good efficacy (day 28 cure rate AS + SP 99% vs CQ 96%), it seems that P. vivax has developed resistance to pyrimetne faster than P. falciparum did.
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Synthesis and anti-glioblastoma effects of  ...

Synthesis and anti-glioblastoma effects of ...

Dec 07, 2018 · A series of novel artemisinin (ART) derivatives containing an isothiocyanate (ITC) group were synthesized. All the compounds showed more potent anti-tumor effects than those of parent dihydroartemisinin (DHA) towards glioblastoma multiforme U87 in vitro.
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Induction of high tolerance to  by sub-lethal ...

Induction of high tolerance to by sub-lethal ...

Jan 17, 2018 · Pandey AV, Tekwani BL, Singh RL, Chauhan VS. Artemisinin, an endoperoxide antimial, disrupts the hemoglobin catabolism and heme detoxification systems in mial parasite. J Biol Chem. 1999 274 (27):19383–19388 [Google Scholar]
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- WikipediaArtemisinin &  in Cancer: Forum, Protocol ...- Wikipedia- Wikipedia

- WikipediaArtemisinin & in Cancer: Forum, Protocol ...- Wikipedia- Wikipedia

People also askIs there resistance to the drug artemisinin in India? See all results for this questionHow does Artemisia annua improve toavailability of artemisinin? See all results for this questionHow is artemisinin used in the treatment of mia? See all results for this questionWhat was the name of the first artemisinin treatment? See all results for this question
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Artemisia and Artemisia-based products for COVID-19 ...

Artemisia and Artemisia-based products for COVID-19 ...

Dec 09, 2020 · In addition to that, artemisinin and its derived molecules showed an extra mode of interaction by binding to Lys353 and Lys31-binding hotspots of SARS-CoV-2 spike protein and producing a better Vina docking score of − 7.1 kcal/mol for artenilic acid than − 5.5 kcal/mol for hydroxychloroquine (Sehailia and Chemat 2020). The study further ...
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: Present status and perspectives

: Present status and perspectives

procedure for the chemical synthesis of artemisinin re-quiresaÞedenovosynthesis of artemisinin is complex, uneconomical and gives low yields, suggesting that isolation from plants would be a better alternative. Biological approach: Plants are the only viable source for the production of artemisinin. Hence, tological
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resistant surveillance in African Plasmodium ...

resistant surveillance in African Plasmodium ...

Artemisinin resistant surveillance in African Plasmodium falciparum isolates from imported mia cases to Italy Mariangela L'Episcopia, Tommaso Ascoli Bartoli , Angela Corpolongo , Andrea Mariano , Alessandra D'Abramo , Antonella Vulcano , Maria G Paglia, Edvige Perrotti , Michela Menegon , Emanuele Nicastri , Carlo Severini
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- Infogalactic: the planetary knowledge core

- Infogalactic: the planetary knowledge core

Artemisinin is isolated from the plant Artemisia annua, sweet wormwood, an herb employed in Chinese traditional medicine. A precursor compound can be produced using genetically engineered yeast. Chemically, artemisinin is a sesquiterpene lactone containing an unusual peroxide bridge. This peroxide is believed to be responsible for the drug's ...
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Use of  and Its Derivatives for the Treatment of ...

Use of and Its Derivatives for the Treatment of ...

Artemisinin for the Treatment of Mia EDITORIAL BOARD Co-Editors: Delane Shingadia and Irja Lutsar Board Members David Burgner (Melbourne, Australia) Luisa Galli (Florence, Italy) Christiana Nascimento-Carvalho (Bahia, Brazil) Ville Peltola (Turku, Finland) Nicole Ritz (Basel, Switzerland) Ira Shah (Mumbai, India) Matthew Snape (Oxford, UK)
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Global  Derivatives Market Status, Trends and ...

Global Derivatives Market Status, Trends and ...

4.4.5 Italy Artemisinin Derivatives Market Size and Price Analysis 4.5 Middle East and Africa 4.5.1 Africa Artemisinin Derivatives Market Size and Price ...
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Artemisinin Antimial Drugs Market 2021 : Detailed ...

Artemisinin Antimial Drugs Market 2021 : Detailed ...

Nov 15, 2021 · Nov 15, 2021 (The Expresswire) -- Global “Artemisinin Antimial Drugs Market" to grow with a impressive CAGR over the forecast period from. The...
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... - For  Science

... - For Science

Jul 02, 2020 · However, artemisinin alone shows little antiviral activity. “I was surprised that A. annua extracts worked noticeably better than pure artemisinine derivatives and that teased activity,” says Klaus Osterrieder, professor of virology at the Free University of Berlin, who carried out all activity tests.
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Artemisinin Derivatives Market- Growth, Size, Share and ...

Artemisinin Derivatives Market- Growth, Size, Share and ...

The Artemisinin Derivatives market was valued at USD 655 million in 2020 and expected to grow at a CAGR of 6.05% during the forecast period from 2021 to 2027 to reach around USD 1,080 million in 2027. Artemisinin derivatives are a group of active pharmaceutical ingredients which are used in treatment against mia.
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Sweet Wormwood -

Sweet Wormwood -

Sweet wormwood contains significant amounts of artemisinin. The remarkable story of the discovery of artemisinin and the proven efficacy of its antimial and cancer-fighting properties by Chinese scientists has been called “one of the great discoveries in medicine in the latter half of the 20th century.” (Citation: 2).Additionally, Artemisinin has antifungal and antiviral properties ...
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Artemisinin Antimial Drugs Market 2021 : Industry ...

Artemisinin Antimial Drugs Market 2021 : Industry ...

Sep 17, 2021 · Sep 17, 2021 (The Expresswire) -- Global “Artemisinin Antimial Drugs Market" is expected to grow at a steady growth during the forecast period,...
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Frontiers | Artemisinins as Anticancer Drugs: Novel ...

Frontiers | Artemisinins as Anticancer Drugs: Novel ...

Artemisinin and its derivatives have shown broad-spectrum antitumor activities in vitro and in vivo. Furthermore, outcomes from a limited number of clinical trials provide encouraging evidence for their excellent antitumor activities. However, some problems such as poor solubility, toxi and controversial mechanisms of action hamper their use as effective antitumor agents in the clinic. In ...
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Semi-synthetic : a model for the use of synthetic ...

Semi-synthetic : a model for the use of synthetic ...

Apr 01, 2014 · Entry of the antimial drug precursor semi-synthetic artemisinin into industrial production is the first major milestone for the application of synthetic biology. In this Review, Paddon and ...
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...

...

Mar 23, 2021 · Artemisinin-preconditioned mice exhibited better spatial learning-memory than LPS-challenged mice. The Y maze test also demonstrated that artemisinin could improve spatial cognition in sepsis models.
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? - Artemisia Annua: La pianta Magica

? - Artemisia Annua: La pianta Magica

Sep 28, 2020 · The active ingredient artemisinin extracted from the plant, Artemisia annua . It is a highly oxygenated sesquiterpene lactone, containing a unique 1,2,4-trioxane ring structure this natural product is used in the fight against mia and therefore falls into the category of antimials . It has a relatively low toxi in humans, even if undesirable effects have also been reported of ...
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New on Pubmed:  ...

New on Pubmed: ...

Jul 31, 2019 · New on Pubmed: artemisia annua and artemisinin effects against canine cancer. Another important article suggesting interesting conclusions about artemisia annua plant and cancer as it shows the major efficacy of the extract derived from the plant compared to the pure artemisinin (SSA, Semi Syntetic Artemisinin) against dogs cancer (osteosarcoma).
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Artemisinin Market Research Report Till 2027: Global ...

Artemisinin Market Research Report Till 2027: Global ...

The report on the Global Artemisinin Market gives an estimation of the development of the market based on historical studies and also provides forecasts on the basis of a comprehensive research. The report gives a complete market analysis for the forecasted period from 2021 to 2027. The market is divided into various segments with an in-depth ...
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Global  API Market Research Report 2021 | Market ...

Global API Market Research Report 2021 | Market ...

Italy Russia Asia-Pacific China ... 1.2.1 Global Artemisinin API Market Size Growth Rate Analysis by Type 2021 VS 2027 ... 2016 VS 2021 VS 2027 1.5.2 North America ...
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surveillance in  Plasmodium ...

surveillance in Plasmodium ...

Dec 09, 2020 · The identification of kelch 13 propeller (Pfk13) gene as a marker of artemisinin resistance 13 has provided the international scientific community with a molecular marker to track in real time the emergence of resistant falciparum isolates before the artemisinin resistance spread in Africa.
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Artemisinin for Cancer, Mia and More

Artemisinin for Cancer, Mia and More

Aug 06, 2021 · According to anecdotal evidence however, individuals have experienced as great as a 28% tumor shrinkage within 16 hours of treatment with artemisinin alone. When used in conjunction with iron, the effects seem to be even better. The main reason that artemisinin is such an effective cancer treatment is that it functions primarily through oxidation.
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...

...

Dec 09, 2020 · Artemisinin resistant surveillance in African Plasmodium falciparum isolates from imported mia cases to Italy J Travel Med . 2020 Dec 9 taaa231. doi: 10.1093/jtm/taaa231.
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-Based Combination Therapy Synergized with ...

-Based Combination Therapy Synergized with ...

Artemisinin-based combination therapy remains effective and well tolerated. But its combination with medicinal plants induced myotoxic effects. This toxi would appear to be of the additive type. Further studies should be able to better elucidate the mechanism of this toxi.
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Artemisinin Derivatives Market Size 2021 Global Gross ...

Artemisinin Derivatives Market Size 2021 Global Gross ...

From 2015 to 2019, the growth rate of global Artemisinin Derivatives market size was in the some range. At the end of 2019, COVID-19 began to erupt in China, Due to the huge decrease of global economy we forecast the growth rate of global economy will show a decrease of about 4%, due to this reason, Artemisinin Derivatives market size in 2020 with a growth rate of percentage.
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Global  Api Market – Market Reports World

Global Api Market – Market Reports World

May 31, 2021 · Global Artemisinin API Market: Drivers and Restrporated the analysis of different factors that augment the market’s growth. It constitutes trends, restraints, and drivers that transform the market in either a positive or negative manner.
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