Use Perilla leaves are used in Chinese medicine to treat a wide variety of ailments, as well as in Asian cooking as a garnish and as a possible antidote to food poisoning. Leaf extracts have shown antioxidant, antiallergic, anti-inflammatory, antidepressant, anorexigenic, and tumor-preventing properties. However, there are limited clinical data to support perilla for any use. Dosing Clinical trials are lacking to provide dosage recommendations. Contraindications Contraindications have not yet been identified. See full list on Perilla is an annual herb indigenous to eastern Asia but which has become naturalized to the southeastern United States, particularly in semishaded, damp woodlands. The plant is attractive, with deep purple, square stems and reddish-purple leaves. The leaves are ovate, hairy, and petiolated, with ruffled or curly edges; some very large red leaves are reminiscent of a slice of raw beef, hence the common name of beefsteak plant. Small tubular flowers are borne on long spikes that arise from the leaf axils between July and October. The plant has a strong fragrance sometimes described as minty.1, 2 See full list on The leaves and seeds are widely eaten in Asia. In Japan, perilla leaves are used as a garnish on raw fish dishes serving the dual purposes of flavoring and as an antidote to possible food poisoning. The seeds are expressed to yield edible oil that is also used in commercial manufacturing processes for the production of varnishes, dyes, and inks. Dried leaves are used for many applicationuding treatment of respiratory conditions (eg, asthma, coughs, colds), as an antispasmodic, to induce sweating, to quell nausea, and to alleviate sunstroke.2, 3 See full list on Perilla leaves yield about 0.2% of a delicately fragrant essential oil that varudes hydrocarbons, alcohols, aldehydes, ketones, and furan. The seeds have a fixed oil content of approximately 40%, with a large proportion of unsaturated fatty acids, mainly alpha-linoleic acid. The plant also contains pseudotannins and antioxidants typical of the mint family. An anthocyanin pigment, perillanin chloride, is responsible for the reddish-purple coloration of some cultivars. Several different chemotypes have been identified. In the most frequently cultivated chemotype, the main component is perillaldehyde, with smaller amounts of limonene, linalool, beta-caryophyllene, menthol, alpha-pinene, perillene, and elemicin. The oxime of perilla aldehyde (perillartin) is reported to be 2,000 times sweeter than sugar and is used as an artificial sweetener in Japan. Other compounds ofude citral, a pleasantly lemon-scented compound; ro... See full list on Antioxidant properties of perilla leaf and seed extracts, as well as individual chemical constituents, have been extensively studied in experimental models5, 7, 8, 9 with limited therapeutic applications evaluated.10, 11, 12, 13, 14 See full list on Clinical trials are lacking to provide dosage recommendations. An extract of perilla enriched to contain 200 mg of rosmarinic acid has been used to treat the symptoms of seasonal allergy.19 Healthy volunteers consumed 5 g of powdered perilla leaves for 10 days in another study.11 See full list on Dermatitis has been reported in perilla oil workers. Patch testing suggests that 1-perillaldehyde and perilla alcohol contained in the oil are responsible for the effect.2, 41 Two cases of anaphylaxis resulting from oral consumption of 500 mg of perilla seeds have been reported. An IgE-mediated response was documented.42 See full list on Animals grazing on perilla have developed fatal pulmonary edema and respiratory distress.43 Perilla ketone, chemically related to the toxic ipomeanols derived from moldy sweet potatoes, is a potent agent for the induction of pulmonary edema in laboratory animals.44 Highest levels of perilla ketone occur in the plant during the floweringeasing the permeability of endothelial cells and may not require the pease vascular permeability.45 The toxicity of perilla ketone has been examined in several animal species.43Low intraperitoneal median lethal dose values were observed for mice and hamsters (5 and 13.7 mg/kg, respectively), with far higher lethal doses being required for dogs and pigs (106 and 158 mg/kg, respectively). Perilla ketone-related pathology in dogs and pigs was primarily hepatic, with only minor pulmonary effects, while mice and hamsters displayed only pulmonary lesions. Enzyme bioactivation of perilla ket... See full list on This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information abude all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using th... 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