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Cost-effective Artemisinin Bulgaria

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ThursdayApril252013 /reports |  ...

ThursdayApril252013 /reports | ...

artemisinin this year, ris-ing to tonnes a year from 2014 – enough form treatments. The elaborate work involves fermentation of artemisinic acid in Bulgaria, photo-chemistry to transform it into artem-isinin in Italy and processing and mix-ing with o t h e r drugs suc’s existing antimial ...
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Dried-leaf Artemisia annua: A practical mia therapeutic ...

Dried-leaf Artemisia annua: A practical mia therapeutic ...

Dec 01, 2014 · In all three studies the administered products had comparable levels of artemisinin, but crude preparations and pACT were at least 3.5 times more effective in reducing parasitemia than pure artemisinin, suggesting a synergistic role for non-artemisinin constituents in the extracts and orally consumed dried leaves.
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Artemisia annua L. extracts inhibit the in vitro replication ...

Artemisia annua L. extracts inhibit the in vitro replication ...

Feb 24, 2021 · Results Hot-water leaf extracts based on artemisinin, total flavonoids, or dry leaf mass showed antiviral activity with IC50 values of.7 μM,.14 μg, and.4 μg, respectively. Antiviral efficacy did not correlate with artemisinin or total flavonoid contents of the extracts.
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Artemisinin derivative of sweet wormwood and its growing ...

Artemisinin derivative of sweet wormwood and its growing ...

Mar 08, 2021 · Artemisinin effectively reduces human herpesvirus 5 when used 300 mg daily, orally for 30 days. Artemisinin also has some antifungal properties against pneumocystis customs. There are several other positive effects on rheumatoid arthritis, renal syndrome, pancreatitis. Artemisinin is firmly established as a cure for malaria in combination therapies. Its great potential now lies in diseases that are a challenge for all of humanity, such as many cancers, and for which currently only expensive ...
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(PDF)  Artemisia ...

(PDF) Artemisia ...

Dec 15, 2018 · Abstract. Artemisia annua is an important medical plant that produces artemisinin used for its antimial, antibacterial and antifungal effects in modern medicine. The high demand and low ...
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eases after ...

eases after ...

Aim of the study: Artemisinin combination therapies (ACTs) are effective for treating mia, but are often unavailable to those in need. Dried leaves of A. annua (DLA) have recently been studied as a cost effective alternative to traditional ACTs.
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path to an optimal future for the Affordable Medicines ...

path to an optimal future for the Affordable Medicines ...

Sep 27, 2011 · In 2004, the Institute of Medicine (IOM) proposed a simple solution to a pressing global problem (Arrow et al. 2004). The price of artemisinin-based combination
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– Medicinal Plants

– Medicinal Plants

Mar 09, 2016 · Similarly the more recent hybrids between Chinese and Vietnamese selections with even higher artemisinin .5%) are only available to a limited extent (). The cost and time involved in carrying out accurate assays for artemisinin have also been other limitations on the screening and selection of Artemisia annua lines.
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(PDF) Dried-leaf Artemisia annua: A practical mia ...

(PDF) Dried-leaf Artemisia annua: A practical mia ...

Artemisinin from the plant Artemisia annua (A. annua) L, and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating mia, a disease that hits children and adults especially in developing countries.
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WHO | Cost–effectiveness of artemisinin combination therapy ...

WHO | Cost–effectiveness of artemisinin combination therapy ...

At a cost per life year saved of US$ 58, A+L appears to be a highly cost-effective and affordable regimen for uncomplicated paediatric mia in Papua New Guime per capita in 2008 was US$ 1040. 24 In a large multicentre trial that compared ARTS with quinine for the treatment of severe maemental cost per death averted by the use of ARTS was US$ 140 from the provider’s perspective, 25 and it was concluded that substituting ...
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WHO | Antimial drug efficacy and drug resistance

WHO | Antimial drug efficacy and drug resistance

Apr 27, 2018 · Artemisinin-based combination therapies and drug resistance WHO recommends ACTs for the treatment of uncomplicated mia caused by P. falciparum . ACTs have been an integral part of the remarkable recent success in global mia control, and there is broad consensus that protecting the efficacy of these combination medicines is an urgent ...
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Frontiers | Studies on Activities and Chemical ...

Frontiers | Studies on Activities and Chemical ...

Artemisinin-based combination therapies (ACTs) are the most recommended treatments for uncomplicated P. falciparum malaria, while artesunate is considered the most effective antimalarial drug for severe cases (Roussel et al., 2017), with several biochemical processes reported as targets in the parasites (Wicht et al., 2020).
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Dried-leaf Artemisia annua: A practical mia therapeutic ...

Dried-leaf Artemisia annua: A practical mia therapeutic ...

Jun 25, 2017 · Artemisinin from the plant Artemisia annua ( A. annua) L., and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating mia, a disease that hits children and adults especially in developing countries. Traditionally, A. annua was used by tnese as a tea to treat “fever”.
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Potential ecological roles of  produced by ...

Potential ecological roles of produced by ...

At present, total chemical synthesis (Abdin et al. 2003) or in vitro production (Arsenault et al. 2008) of the relatively complex structure artemisinin is not economically feasible, and cultivation of the plant is still the only cost effective source of artemisinin.
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Early Research Finds Extracts from Sweet Wormwood Plant Can ...

Early Research Finds Extracts from Sweet Wormwood Plant Can ...

May 04, 2021 · “A. annua could provide clues to new safe, cost-effective small molecule therapies or even be used as an antiviral nutraceutical.” The researchers soaked dried leaves of A. annua, obtained from four continents in hot water and tested the solutions against SARS-CoV-2 and two variants originating from the United Kingdom and South Africa. Some ...
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Cost effectiveness analysis of strategies to combat ...

Cost effectiveness analysis of strategies to combat ...

Dec 01, 2005 · In Afr-D, case management with artemisinin based combination treatments at 80% target coverage is the most cost effective intervention overall and would be the first choice where resources are limited, whereas a target coverage of 95% is needed in Afr-E.
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Production of the antimial drug precursor artemisinic ...

Production of the antimial drug precursor artemisinic ...

Apr 13, 2006 · Artemisinin, a sesquiterpene lactone endoperoxide extracted from Artemisia annua L (family Asteraceae commonly known as sweet wormwood), is highly effective against multi-drug-resistant ...
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A THRESHOLD ANALYSIS OF THE -EFFECTIVENESS OF  ...

A THRESHOLD ANALYSIS OF THE -EFFECTIVENESS OF ...

Cost-Effectiveness of the Introduction of a Pre-Erythrocytic Mia Vaccine into the Expanded Program on Immunization in Sub-Saharan Africa: Analysis of Uncertainties Using a Stochastic Individual-Based Simulation Model of Plasmodium falciparum Mia
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combat mia ...

combat mia ...

Dec 01, 2005 · In Afr-D, case management with artemisinin based combination treatments at 80% target coverage is the most cost effective intervention overall and would be the first choice where resources are limited, whereas a target coverage of 95% is needed in Afr-E.
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Hepatocellular carcinoma treatment and experiments with ...

Hepatocellular carcinoma treatment and experiments with ...

Mar 08, 2021 · Artemisinin study 2. The second study was conducted by Dr. YP Vandewyncel and his team 2014 to find therapeutic effects of artesunate on hepatocellular cancer. The main objectives of the study were evaluation and effects on tumor growth, anginogenesis, protein reactions and chemoresistance of hepatocellular carcinoma.
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Sixteenth Board Meeting - The Global Fund

Sixteenth Board Meeting - The Global Fund

The Global Fund Twenty-Second Board Meeting GF/B22/11, Revision 1 Sofia, Bulgaria, 13–15 December 2010 2/29 PART 1: INTRODUCTION 1.1 The Market Dynamics and Commodities Ad-hoc Committee (MDC) held its 3rd Meeting on 14 and 15 October 2010 in Geneva.
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to create powerful,  ...

to create powerful, ...

Jul 27, 2020 · Using the much simpler synthesis technique created by Blumberg and Frantz, they plan to revisit these potent artemisinin derivatives to ost-effective manner.
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Fully electrochemical MIP sensor for  - ScienceDirect

Fully electrochemical MIP sensor for - ScienceDirect

Dec 01, 2018 · This study aims to develop a rapid, sensitive and cost-effective biomimetic electrochemical sensor for artemisinin determination in plant extracts and for pharmacokinetic studies. A novel molecularly imprinted polymer (MIP)-based electrochemical sensor was developed by electropolymerization of o-phenylenediamine (o-PD) in the presence of ...
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Developing an industrial artemisinic acid fermentation ...

Developing an industrial artemisinic acid fermentation ...

Sep 17, 2008 · The full text of this article hosted at is unavailable due to technical difficulties.
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REVIEW PAPER MUTUALISTIC AND ENDOPHYTIC …

REVIEW PAPER MUTUALISTIC AND ENDOPHYTIC …

uneconomical, non-cost-effective and low yielding (Pandey and Pandey-Rai, 2015), however microbial genetic engineering is a potential alternative (Hommel, 2008). Progress has been made towards breaking the cost/yield barrier while it is yet unproven as commercially viable syntheses of …
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–effectiveness of  combination therapy for ...

–effectiveness of combination therapy for ...

cost per life year saved. Findings A+L proved to be the most effective regimen against . ciparum f. mia and was highly cost-effective at 6.97 United States dollars (US$) per treatment success (about US$ 58 per life year saved). DHA+PQ was the most effective regimen against . P.ivax v. mia and was more cost-effective than CQ+S+P.
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...

...

Sep 17, 2008 · Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies Jacob R. Lenihan , Amyris Biotechnologies, 5980 Horton Street, Suite 450, Emeryville, CA 94608
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derivative of sweet wormwood and its growing ...

derivative of sweet wormwood and its growing ...

Mar 08, 2021 · Artemisinin derivative of sweet wormwood and its growing importance in medicine. Artemisinin is obtained from the sweet wormwood extract and has so far been found to be excellent uding highly resistant strains of this parasite. Its effectiveness has also been shown in parasitic infections such as schistosomiasis.
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Artemisia annua L. extracts inhibit the in vitro replication ...

Artemisia annua L. extracts inhibit the in vitro replication ...

While all hot water extracts were effective, concentrations of artemisinin and total flavonoids varied by nearly 100-fold in the extracts. Artemisinin alone showed an estimated IC 50 of about 70 μM, and the clinically used artemisinin derivatives artesunate, artemether, and dihydroartemisinin were ineffective or cytotoxic at elevated ...
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Structures of  (1)  Q260 (2), the UVÀvisible ...

Structures of (1) Q260 (2), the UVÀvisible ...

GC [8,14] reduces pollution caused by organic solvents, and is environmentally friendly and cost-effective. UV traces obtained on HPLC and liquid chromatography (LC)-MS instruments have been shown ...
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Bioinspired Microenvironment Responsive oprodrug as an ...

Bioinspired Microenvironment Responsive oprodrug as an ...

Artemisinin compounds have shown satisfactory safety records in anti-mial clinical practice over decades and have revealed value as inexpensive anti-tumor adjuvant chemotherapeutic drugs. However, the rational design and precise preparation of omedicines based on the artemisinin drugs are sti …
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Artemisinin derivative of sweet wormwood and its growing ...

Artemisinin derivative of sweet wormwood and its growing ...

Mar 08, 2021 · Artemisinin is obtained from the sweet wormwood extract and has so far been found to be excellent uding highly resistant strains of this parasite. Its effectiveness has also been shown in parasitic infections such as schistosomiasis. Sweet wormwood has shown great influence, and broad properties in carcinogenic diseases and tests have been …
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of  ...

of ...

Jan 11, 2021 · All extracts demonstrated anti-SARS-CoV-2 activity. The IC50 values (concentration of drug that inhibits 50% of target) calculated based on artemisinin, total flavonoid content or dry leaf mass ...
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Ivermectin for COVID-19: real-time analysis of all 130 studies

Ivermectin for COVID-19: real-time analysis of all 130 studies

Ivermectin for COVID-19: real-time meta analysis of 66 studies: Details • Statistically significant improvements are seen for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance. All remain statistically significant after exclusions. 44 studies show statistically signi..
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Developing an  ...

Developing an ...

Developing an industrial artesimic acid fermentation process to support the cost- effective production of anti-mial artemisinin-based combination therapies (ACTs) September 2008 Biotechnology ...
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Cost-effectiveness of artemisinin-naphthoquine versus ...

Cost-effectiveness of artemisinin-naphthoquine versus ...

Background: A recent randomized trial showed that artemisinin-naphthoquine (AN) was non-inferior to artemether-lumefantrine (AL) for falciparum mia and superior for vivax mia in young Papua New Guinean children. The aim of this study was to compare the cost-effectiveness of themental cost-effectiveness analysis was performed using data from 231 ...
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