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Cost-effective Artemisinin Bulgaria

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ThursdayApril252013 www.ft.com/reports | twitter.com ...

ThursdayApril252013 www.ft.com/reports | twitter.com ...

artemisinin this year, ris-ing to 50-60 tonnes a year from 2014 – enough for 80-150m treatments. The elaborate work involves fermentation of artemisinic acid in Bulgaria, photo-chemistry to transform it into artem-isinin in Italy and processing and mix-ing with o t h e r drugs such as amodi-aquine, one of the company’s existing antimalarial ...
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Dried-leaf Artemisia annua: A practical malaria therapeutic ...

Dried-leaf Artemisia annua: A practical malaria therapeutic ...

Dec 01, 2014 · In all three studies the administered products had comparable levels of artemisinin, but crude preparations and pACT were at least 3.5 times more effective in reducing parasitemia than pure artemisinin, suggesting a synergistic role for non-artemisinin constituents in the extracts and orally consumed dried leaves.
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Artemisia annua L. extracts inhibit the in vitro replication ...

Artemisia annua L. extracts inhibit the in vitro replication ...

Feb 24, 2021 · Results Hot-water leaf extracts based on artemisinin, total flavonoids, or dry leaf mass showed antiviral activity with IC50 values of 0.1-8.7 μM, 0.01-0.14 μg, and 23.4-57.4 μg, respectively. Antiviral efficacy did not correlate with artemisinin or total flavonoid contents of the extracts.
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Artemisinin derivative of sweet wormwood and its growing ...

Artemisinin derivative of sweet wormwood and its growing ...

Mar 08, 2021 · Artemisinin effectively reduces human herpesvirus 5 when used 300 mg daily, orally for 30 days. Artemisinin also has some antifungal properties against pneumocystis customs. There are several other positive effects on rheumatoid arthritis, renal syndrome, pancreatitis. Artemisinin is firmly established as a cure for malaria in combination therapies. Its great potential now lies in diseases that are a challenge for all of humanity, such as many cancers, and for which currently only expensive ...
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(PDF)  Artemisia ...

(PDF) Artemisia ...

Dec 15, 2018 · Abstract. Artemisia annua is an important medical plant that produces artemisinin used for its antimalarial, antibacterial and antifungal effects in modern medicine. The high demand and low ...
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permeability via Caco-2 cells increases after ...

permeability via Caco-2 cells increases after ...

Aim of the study: Artemisinin combination therapies (ACTs) are effective for treating malaria, but are often unavailable to those in need. Dried leaves of A. annua (DLA) have recently been studied as a cost effective alternative to traditional ACTs.
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path to an optimal future for the Affordable Medicines ...

path to an optimal future for the Affordable Medicines ...

Sep 27, 2011 · In 2004, the Institute of Medicine (IOM) proposed a simple solution to a pressing global problem (Arrow et al. 2004). The price of artemisinin-based combination
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– Medicinal Plants

– Medicinal Plants

Mar 09, 2016 · Similarly the more recent hybrids between Chinese and Vietnamese selections with even higher artemisinin (1.0-1.5%) are only available to a limited extent (). The cost and time involved in carrying out accurate assays for artemisinin have also been other limitations on the screening and selection of Artemisia annua lines.
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(PDF) Dried-leaf Artemisia annua: A practical malaria ...

(PDF) Dried-leaf Artemisia annua: A practical malaria ...

Artemisinin from the plant Artemisia annua (A. annua) L, and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in developing countries.
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WHO | Cost–effectiveness of artemisinin combination therapy ...

WHO | Cost–effectiveness of artemisinin combination therapy ...

At a cost per life year saved of US$ 58, A+L appears to be a highly cost-effective and affordable regimen for uncomplicated paediatric malaria in Papua New Guinea, where the gross national income per capita in 2008 was US$ 1040. 24 In a large multicentre trial that compared ARTS with quinine for the treatment of severe malaria in south-east Asia, the incremental cost per death averted by the use of ARTS was US$ 140 from the provider’s perspective, 25 and it was concluded that substituting ...
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WHO | Antimalarial drug efficacy and drug resistance

WHO | Antimalarial drug efficacy and drug resistance

Apr 27, 2018 · Artemisinin-based combination therapies and drug resistance WHO recommends ACTs for the treatment of uncomplicated malaria caused by P. falciparum . ACTs have been an integral part of the remarkable recent success in global malaria control, and there is broad consensus that protecting the efficacy of these combination medicines is an urgent ...
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Frontiers | Studies on Activities and Chemical ...

Frontiers | Studies on Activities and Chemical ...

Artemisinin-based combination therapies (ACTs) are the most recommended treatments for uncomplicated P. falciparum malaria, while artesunate is considered the most effective antimalarial drug for severe cases (Roussel et al., 2017), with several biochemical processes reported as targets in the parasites (Wicht et al., 2020).
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Dried-leaf Artemisia annua: A practical malaria therapeutic ...

Dried-leaf Artemisia annua: A practical malaria therapeutic ...

Jun 25, 2017 · Artemisinin from the plant Artemisia annua ( A. annua) L., and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in developing countries. Traditionally, A. annua was used by the Chinese as a tea to treat “fever”.
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Potential ecological roles of  produced by ...

Potential ecological roles of produced by ...

At present, total chemical synthesis (Abdin et al. 2003) or in vitro production (Arsenault et al. 2008) of the relatively complex structure artemisinin is not economically feasible, and cultivation of the plant is still the only cost effective source of artemisinin.
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Early Research Finds Extracts from Sweet Wormwood Plant Can ...

Early Research Finds Extracts from Sweet Wormwood Plant Can ...

May 04, 2021 · “A. annua could provide clues to new safe, cost-effective small molecule therapies or even be used as an antiviral nutraceutical.” The researchers soaked dried leaves of A. annua, obtained from four continents in hot water and tested the solutions against SARS-CoV-2 and two variants originating from the United Kingdom and South Africa. Some ...
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Cost effectiveness analysis of strategies to combat ...

Cost effectiveness analysis of strategies to combat ...

Dec 01, 2005 · In Afr-D, case management with artemisinin based combination treatments at 80% target coverage is the most cost effective intervention overall and would be the first choice where resources are limited, whereas a target coverage of 95% is needed in Afr-E.
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Production of the antimalarial drug precursor artemisinic ...

Production of the antimalarial drug precursor artemisinic ...

Apr 13, 2006 · Artemisinin, a sesquiterpene lactone endoperoxide extracted from Artemisia annua L (family Asteraceae; commonly known as sweet wormwood), is highly effective against multi-drug-resistant ...
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A THRESHOLD ANALYSIS OF THE -EFFECTIVENESS OF  ...

A THRESHOLD ANALYSIS OF THE -EFFECTIVENESS OF ...

Cost-Effectiveness of the Introduction of a Pre-Erythrocytic Malaria Vaccine into the Expanded Program on Immunization in Sub-Saharan Africa: Analysis of Uncertainties Using a Stochastic Individual-Based Simulation Model of Plasmodium falciparum Malaria
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combat malaria ...

combat malaria ...

Dec 01, 2005 · In Afr-D, case management with artemisinin based combination treatments at 80% target coverage is the most cost effective intervention overall and would be the first choice where resources are limited, whereas a target coverage of 95% is needed in Afr-E.
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Hepatocellular carcinoma treatment and experiments with ...

Hepatocellular carcinoma treatment and experiments with ...

Mar 08, 2021 · Artemisinin study 2. The second study was conducted by Dr. YP Vandewyncel and his team 2014 to find therapeutic effects of artesunate on hepatocellular cancer. The main objectives of the study were evaluation and effects on tumor growth, anginogenesis, protein reactions and chemoresistance of hepatocellular carcinoma.
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Sixteenth Board Meeting - The Global Fund

Sixteenth Board Meeting - The Global Fund

The Global Fund Twenty-Second Board Meeting GF/B22/11, Revision 1 Sofia, Bulgaria, 13–15 December 2010 2/29 PART 1: INTRODUCTION 1.1 The Market Dynamics and Commodities Ad-hoc Committee (MDC) held its 3rd Meeting on 14 and 15 October 2010 in Geneva.
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to create powerful,  ...

to create powerful, ...

Jul 27, 2020 · Using the much simpler synthesis technique created by Blumberg and Frantz, they plan to revisit these potent artemisinin derivatives to ost-effective manner.
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Fully electrochemical MIP sensor for  - ScienceDirect

Fully electrochemical MIP sensor for - ScienceDirect

Dec 01, 2018 · This study aims to develop a rapid, sensitive and cost-effective biomimetic electrochemical sensor for artemisinin determination in plant extracts and for pharmacokinetic studies. A novel molecularly imprinted polymer (MIP)-based electrochemical sensor was developed by electropolymerization of o-phenylenediamine (o-PD) in the presence of ...
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Developing an industrial artemisinic acid fermentation ...

Developing an industrial artemisinic acid fermentation ...

Sep 17, 2008 · The full text of this article hosted at iucr.org is unavailable due to technical difficulties.
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REVIEW PAPER MUTUALISTIC AND ENDOPHYTIC …

REVIEW PAPER MUTUALISTIC AND ENDOPHYTIC …

uneconomical, non-cost-effective and low yielding (Pandey and Pandey-Rai, 2015), however microbial genetic engineering is a potential alternative (Hommel, 2008). Progress has been made towards breaking the cost/yield barrier while it is yet unproven as commercially viable syntheses of …
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Artemisia annua L. extracts inhibit the in vitro replication ...

Artemisia annua L. extracts inhibit the in vitro replication ...

While all hot water extracts were effective, concentrations of artemisinin and total flavonoids varied by nearly 100-fold in the extracts. Artemisinin alone showed an estimated IC 50 of about 70 μM, and the clinically used artemisinin derivatives artesunate, artemether, and dihydroartemisinin were ineffective or cytotoxic at elevated ...
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Structures of  (1); Q260 (2), the UVÀvisible ...

Structures of (1); Q260 (2), the UVÀvisible ...

GC [8,14] reduces pollution caused by organic solvents, and is environmentally friendly and cost-effective. UV traces obtained on HPLC and liquid chromatography (LC)-MS instruments have been shown ...
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Bioinspired Microenvironment Responsive Nanoprodrug as an ...

Bioinspired Microenvironment Responsive Nanoprodrug as an ...

Artemisinin compounds have shown satisfactory safety records in anti-malarial clinical practice over decades and have revealed value as inexpensive anti-tumor adjuvant chemotherapeutic drugs. However, the rational design and precise preparation of nanomedicines based on the artemisinin drugs are sti …
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Artemisinin derivative of sweet wormwood and its growing ...

Artemisinin derivative of sweet wormwood and its growing ...

Mar 08, 2021 · Artemisinin is obtained from the sweet wormwood extract and has so far been found to be excellent for the treatment of malaria, including highly resistant strains of this parasite. Its effectiveness has also been shown in parasitic infections such as schistosomiasis. Sweet wormwood has shown great influence, and broad properties in carcinogenic diseases and tests have been …
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Extract of  ...

Extract of ...

Jan 11, 2021 · All extracts demonstrated anti-SARS-CoV-2 activity. The IC50 values (concentration of drug that inhibits 50% of target) calculated based on artemisinin, total flavonoid content or dry leaf mass ...
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Ivermectin for COVID-19: real-time analysis of all 130 studies

Ivermectin for COVID-19: real-time analysis of all 130 studies

Ivermectin for COVID-19: real-time meta analysis of 66 studies: Details • Statistically significant improvements are seen for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance. All remain statistically significant after exclusions. 44 studies show statistically signi..
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Developing an  ...

Developing an ...

Developing an industrial artesimic acid fermentation process to support the cost- effective production of anti-malarial artemisinin-based combination therapies (ACTs) September 2008 Biotechnology ...
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Cost-effectiveness of artemisinin-naphthoquine versus ...

Cost-effectiveness of artemisinin-naphthoquine versus ...

Background: A recent randomized trial showed that artemisinin-naphthoquine (AN) was non-inferior to artemether-lumefantrine (AL) for falciparum malaria and superior for vivax malaria in young Papua New Guinean children. The aim of this study was to compare the cost-effectiveness of these two regimens. Methods: An incremental cost-effectiveness analysis was performed using data from 231 ...
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Developing an Industrial Artemisinic Acid Fermentation ...

Developing an Industrial Artemisinic Acid Fermentation ...

Support the Cost-Effective Production of Antimalarial Artemisinin-Based Combination Therapies Jacob R. Lenihan, Hiroko Tsuruta, Don Diola, Neil S. Renninger, and Rika Regentin Amyris Biotechnologies, 5980 Horton Street, Suite 450, Emeryville, CA 94608 DOI 10.1021/bp.27
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Uses, Benefits & Dosage -  Herbal ...

Uses, Benefits & Dosage - Herbal ...

Mar 22, 2021 · Artemisinin delayed (P < 0.002), and in some rats prevented (57% of artemisinin-fed versus 96% of the controls, P < 0.01), breast cancer development. In the artemisinin-fed rats that developed a tumor, tumor size was smaller ( P < 0.05), and there was a longer duration of time for tumor development (29.4 vs 15.3 weeks) when compared with ...
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Dried-leaf Artemisia annua: A practical malaria ...

Dried-leaf Artemisia annua: A practical malaria ...

Dec 09, 2014 · Artemisinin from the plant Artemisia annua (A. annua) L, and used as artemisinin combination therapy (ACT), is the current best therapeutic for treating malaria, a disease that hits children and adults especially in developing countries. Traditionally, A. annua was used by the Chinese as a tea to treat “fever”. More recently, investigators have shown that tea infusions and oral consumption ...
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Artemisia Annua Extract Powder  99% Pure Sweet | Etsy

Artemisia Annua Extract Powder 99% Pure Sweet | Etsy

Bush Doctor It`s all about making healthier choices in life. Artemisia Annua Extract Powder Artemisinin 99% Pure Sweet Wormwood 10g, 25g, 50g, 100g and 200g we are passionate about premium quality only. Artemisia annua is a medicinal plant whose use has long been reported in China, where it is
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Artemisinin for Cancer, Malaria and More

Artemisinin for Cancer, Malaria and More

Aug 06, 2021 · Artemisinin for Cancer, Malaria and More. Artemisinin has earned some skepticism in past years for its variety of suggested purposes. With its use as an herbicide, some may be slightly wary of using it as an effective herbal remedy; however, the treatment is just that. This pharmaceutical compound has recently earned status as a potent cancer ...
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... | Wellcome Open ...

... | Wellcome Open ...

Apr 07, 2021 · Introduction. In the early 2000s, following widespread development of antimalarial drug resistance to hitherto effective monotherapies, such as chloroquine and sulphadoxine-pyrimethamine (SP), the World Health Organization (WHO) recommended artemisinin-based combination therapies (ACTs) as an approach to improve therapeutic efficacy and delay the development of antimalarial drug resistance ().
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Capsules, Non prescription, Treatment: Covid ...

Capsules, Non prescription, Treatment: Covid ...

MEDISELLER ( A unit of MEDICARE) - Offering Artemisinin Capsules, Non prescription, Treatment: Covid Precautions Medicine at Rs 999/bottle in New Delhi, Delhi. Read about company. Get contact details and address | ID: 248
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