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Cost-effective Shikimic Acid Lithuania

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exudates and ...

exudates and ...

Jun 13, 2016 · Determination with authentic compounds (Table 1) showed that 1,9-decanediol had an inhibitory effect of 21.3% when provided at 20 ng μl −1 and of 97.6% when provided at 200 ng μl −1, whereas no effect was detected with shikimic acid. Moreover, 1,9-decanediol was identified in root exudates collected under both natural and aseptic ...
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L. analytical ...

L. analytical ...

Mar 07, 2017 · Citric acid and malic acid were quantified and determined in a concentration of 0.9–2.3% and 2.3–3.1% in the extracts, respectively. 85. In one experiment, hyperforin was detected using atmospheric pressure chemical ionization and precursor ion m/z 537 and fragment ion m/z 277 were used for quantitation. 27
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Flu -  Flu ...

Flu - Flu ...

Mar 27, 2009 · The New York Times article cites an unnamed Roche chemist who said that 13 grams of star anise could produce 1.3 grams of shikimic acid, which then could be used to make 10 Tamiflu capsules, the amount required to treat one person. Thus, one ton of shikimic acid could treat 770,000 people.
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SURAMIN+  FORMULA (pine needles, Star Anise ...

SURAMIN+ FORMULA (pine needles, Star Anise ...

Oct 19, 2021 · ORGANIC PINE NEEDLE 10:1 EXTRACT POWDER (SURAMIN SHIKIMIC ACID) 100 GRAMS! New New New. $27.19. ... Shipping cost cannot be calculated. Please enter a valid ZIP Code.
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Is pine needle tea the answer to covid vaccine shedding ...

Is pine needle tea the answer to covid vaccine shedding ...

May 10, 2021 · Because of the relative high content and good antiplatelet-aggregating activity of shikimic acid, the Masson pine needles can be used as a potential source of shikimic acid. …achieved about a 6% yield of shikimic acid from Masson pine needles, which is possibly the highest extracted yield from any pine species till now (Chen et al. 2014).
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India's trees are potential Tamiflu source

India's trees are potential Tamiflu source

Apr 01, 2009 · Plants meet two-thirds of the requirements for shikimic acid and the remaining one-third is met by engineering the bacterium Escherichia coli to produce the chemical — which is not cost-effective. The researchers screened 210 tree species in the Western Ghats region for shikimic acid content and shortlisted seven trees that contain 1–5 per ...
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Improved growth, productivity and quality of tomato (Solanum ...

Improved growth, productivity and quality of tomato (Solanum ...

A field experiment was conducted to investigate the effect of seed presoaking of shikimic acid (30, 60 and 120 ppm) on growth parameters, fruit productivity and quality, transpiration rate, photosynthetic pigments and some mineral nutrition contents of tomato plants.
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Evaluation of spectrophotometric and HPLC methods for ...

Evaluation of spectrophotometric and HPLC methods for ...

Endogenous shikimic acid determinations are routinely used to assess the efficacy of glyphosate in plants. Numerous analytical methods exist in the public domain for the detection of shikimic acid, yet the most commonly cited comprise spectrophotometric and high-pressure liquid chromatography (HPLC) methods.
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, a base compound for the formulation of swine ...

, a base compound for the formulation of swine ...

source of shikimic , both the raw materials are in short supplies, the pharmaceutical industry needs to find an alternative sustainable supply which is time independent and cost effective. Interestingly, it was confirmed later that shikimic acid is also a natural intermediate in the formation of
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Shikimic acid as intermediary model for the production of ...

Shikimic acid as intermediary model for the production of ...

Jan 24, 2020 · This chapter explains the application of shikimic acid as preventive medicine for the outbreak of swine or Avian flu due to H1N1 virus. Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid), a natural organic compound, is generally utilized as a starting material for industrial synthesis of the antiviral oseltamivir, a drug against the H1N1 influenza virus.
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Roundup Alternatives - The Popular Herbicide Will Soon Be No More

Roundup Alternatives - The Popular Herbicide Will Soon Be No More

Sep 03, 2021 · The chemical is highly-effective, killing most grasses, weeds, and vines with one application. Glyphosate eliminates weeds by interrupting the shikimic acid pathway. Once it interrupts the pathways, enzymes essential to life are no longer produced. Most plants and grasses die seven to ten days post-application.
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Shikimic acid (shikimate) is an important biochemical metabolite in plants and microorganisms. It is also essential for a healthy microbiome. It has long been known that shikimic acid reduces platelet aggregation and fights cancer. When taken with quercetin it also effectively modulates the body's innate immunity against viral infections
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Dr. Michael McDowell - Genetic BIOWEAPONS unleashed by VIRUS ...

Dr. Michael McDowell - Genetic BIOWEAPONS unleashed by VIRUS ...

Nov 20, 2021 · Effective Treatments ... 3 Foods That Contain Shikimic Acid to Halt Spike Protein ... My wife's charges were dismissed after great effort and cost and our daughter ...
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Method for the extraction and purification of   ...

Method for the extraction and purification of ...

Dec 23, 2005 · 3. Purification of shikimic acid by Diaion HP-20 adsorbent resin chromatography with water elution, followed by second purification by Amberlite IRA-400 chromatography with acetic acid elution. IV. Shikimic Acid Detection Method (Specific Examples 1, 2, 3, and 6) (see FIG. 14): 1. Approximately 1 g of dried, ground plant material. 2.
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Vietnam successfully extracted   from star anise ...

Vietnam successfully extracted from star anise ...

Aug 03, 2020 · According to the above process, every 100 kg of star anise will extract kg of pure shikimic. However, scientists continue to perfect the technology to achieve optimal results in terms of cost, efficiency and quality. Due to skyrocketing world demand for oseltamivir, shikimic prices in the world market have escalated to US $ / kg.
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- an overview | ScienceDirect TopicsGrandma Was Right Again! – Separation of Shikimic Acid ...A Comprehensive ReviewA Comprehensive Review

- an overview | ScienceDirect TopicsGrandma Was Right Again! – Separation of Shikimic Acid ...A Comprehensive ReviewA Comprehensive Review

People also askWhich is more expensive shikimic acid or quinic acid? See all results for this questionWhat is the purity of shikimic acid crystals? See all results for this questionAre there any side effects to taking shikimic acid? See all results for this questionWhy is shikimic acid good for the intestinal tract? See all results for this question
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Studies on the production of   using the aroK ...

Studies on the production of using the aroK ...

Jun 23, 2016 · Fig. 6 Course of growth and 50 5 8 9.0 120 shikimic acid production in a 14 L bioreactor using the DaroK 40 100 strain of B. megaterium 6 8.5 4 8.0 60 2 7.5 0 0 7.0 0 010 20 30 40 50 Time (h) pH Shikimic acid Dry cell weight DO Fructose concentration Shikimic acid (g/L) Fructose concentration (g/L) Dry cell weight (g/L) Dry Cell weight (g/L ...
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| Podcast | Chemistry World

| Podcast | Chemistry World

The cost of raw shikimic acid can vary by up to 100 per cent, depending on whether a flu outbreak is imminent These properties make glyphosate a broadly very safe and effective herbicide, but because the shikimate pathway exists in crop plants as well as weeds, it can’t distinguish between the two.
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Advances and Prospects of Phenolic Acids Production ...

Advances and Prospects of Phenolic Acids Production ...

Jun 06, 2020 · Only lactic acid bacteria such as Lactobacillus arizononas R13, Lactobacillus plantarum FST1.7, Lactobacillus reuteri R2, and Weisella cibaria PS2 can produce vanillic acid (up to 4.3 mg/L), p-hydroxybenzoic acid (up to 1.5 mg/L), ρ-coumaric acid (up to 14.0 mg/L), and salicylic acid (up to 9.9 mg/L) from the glucose using de Man, Rogosa and ...
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| CAS-1 |   derivative ...

| CAS-1 | derivative ...

For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @ or click below button.
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to   by ...

to by ...

Jul 31, 2014 · Still, there is a need to develop cost-effective and better alternative method for shikimic acid production. Microbial biotransformation has been used for the production of shikimic acid from quinic acid in recent few years as a potent alternative of the available methods [ 16 ],[ 17 ].
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years on: Advent of ...

years on: Advent of ...

Sep 11, 2020 · Tamiflu was discovered by Gilead Sciences in 1995, patented in 1996, co-developed with F. Hoffmann-La Roche Ltd and marketed by F. Hoffmann-La Roche and commercially launched in November 1999 [, , , , , ] In the early years of its discovery, (−)-shikimic acid was used as starting material for the synthesis of Tamifd furthermore, the current and only industrial synthetic route still uses ...
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losynth |

losynth |

INTERMEDIATE NAME CHEMICAL NAME CHEMICAL STRUCTURE CAS recombit Shikimic Acid (3R,4S,5R)-3,4,5-trihydroxycyclohexene-1-carboxylic acid:
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Frontiers | Metabolic Engineering of  -Producing ...

Frontiers | Metabolic Engineering of -Producing ...

Sep 10, 2020 · When cellobiose was used as a carbon source, the strain produced shikimic acid at 13.8 g/L with the yield of 0.25 g-shikimic acid/g-glucose (1 g of cellobiose corresponds to 1.1 g of glucose). These results demonstrate the feasibility of producing shikimic acid and its derivatives using an engineered C. glutamicum strain from cellobiose as well ...
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Is Pine Needle Tea, Suramin, & Shakimic Acid The Answer To ...

Is Pine Needle Tea, Suramin, & Shakimic Acid The Answer To ...

May 18, 2021 · Because of the relative high content and good antiplatelet-aggregating activity of shikimic acid, the Masson pine needles can be used as a potential source of shikimic acid. Achieved about a 6% yield of shikimic acid from Masson pine needles, which is possibly the highest extracted yield from any pine species till now (Chen et al. 2014).
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as  of ...

as of ...

Jan 01, 2020 · This chapter explains the application of shikimic acid as preventive medicine for the outbreak of swine or Avian flu due to H1N1 virus. Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid), a natural organic compound, is generally utilized as a starting material for industrial synthesis of the antiviral oseltamivir, a drug against the H1N1 influenza virus.
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Antidote  ...

Antidote ...

May 16, 2021 · Because of the relative high content and good antiplatelet-aggregating activity of shikimic acid, the Masson pine needles can be used as a potential source of shikimic acid. …achieved about a 6% yield of shikimic acid from Masson pine needles, which is possibly the highest extracted yield from any pine species till now (Chen et al. 2014).
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Chemicals from Biomass

Chemicals from Biomass

Nov 23, 2007 · Recently, there has been a strong political and technical focus on using biomass to produce transportation fuels (1, 2). Much less attention has been given to biomass as a feedstock for organic chemicals. Replacement of petroleum-derived chemicals with those from biomass will play a key role in sustaining the growth of the chemical industry.
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Shikimic acid from staranise (Illicium verum Hook ...

Shikimic acid from staranise (Illicium verum Hook ...

Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) is considered as an essential biochemical metabolite in autotrophic organisms, such as plants and some bacteria, which is used to procreate the anti-influenza drug oseltamivir. Generally speaking, there are three main methods to prouded in the chemical synthesis and microbial fer Additional ...
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Evaluation of spectrophotometric and HPLC methods for ...

Evaluation of spectrophotometric and HPLC methods for ...

Overall, spectrophotometric methods were more cost-effective and simpler to execute yet provided a narrower detection limit compared to HPLC. All three methods were specific to shikimic acid and detected the compound in the tissues of easing exponentially in concentration within 24 h of glyphosate application ...
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Recent Development in Synthetic Strategies for Oseltamivir ...

Recent Development in Synthetic Strategies for Oseltamivir ...

Currently, the drug is produced in an industrial process of 11 chemical steps starting from (–)‐shikimic acid, whose availability is limited due to the massive demand of the drug. Thus, many chemists have been working to develop alternative synthetic processes to produce this important drug starting from readily available materials using ...
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an ...

an ...

Jul 13, 2016 · Kramer, M. et al. Metabolic engineering for microbial production of shikimic acid. Metab Eng. 5, 277–283 (2003). CAS Article Google Scholar
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Content Analysis of Shikimic Acid in the Masson Pine ...

Content Analysis of Shikimic Acid in the Masson Pine ...

The results showed that the shikimic acid content in Masson pine needles, Oriental arborvitae leafytwigs and Star anise was 5.71%, 1.74% and 8.95%, respectively. The yield of shikimic acid was the ...
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Quality and Authenti Control of Fruit Juices-A Review

Quality and Authenti Control of Fruit Juices-A Review

Mar 13, 2019 · This approach is commonly employed by quality-control labs, as it is a rapid and cost-effective way to primarily assess the authenti of a fruit juice. Values are compared to those reported by the AIJN which have been determined in 100% pure juices and are internationally accepted by producers, users and control agencies.
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Shikimic acid from staranise (Illicium verum Hook ...

Shikimic acid from staranise (Illicium verum Hook ...

Shikimic acid from staranise (Illicium verum Hook): Extraction, purification and determination ... cost-effective for pharmaceutical and cosmetic industries In Roche,, dried star anise is utilized for production of it ].
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No identified covid-19 virus says CDC

No identified covid-19 virus says CDC

Star Anise (Shikimic acid is the key raw material for the manufacture of oseltamivir (Tamiflu), an anti-viral drug.) Note: This product is brewed in 100 proof alcohol we dilute it to 90 Proof for shipping . Suggested 1/4 - 1 teaspoon a day.
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