The ongoing coronavirus disease 2019 (COVID-19) pandemic, which is caused by the spreaease morbidity and mortality across the world. Mitigation strategies and vaccinations have declined the infection rate and severity; however, there are limited therapeutic options that are currently available for treating COVID-19. Traditional herbal medicines are a promising option for the complementary treatment of COVID-19. The rhizome of Curcuma longa, which is more commonly known as turmeric root, is one popular option that is associated with potent antiviral propeude curcumin (75%), demethoxycurcumin (20–25%), and bisdemethoxycurcumin (5–15%), all of which have a broad spectrum of bioactivities such as antioxidant, anti-inflammatory, antibacterial, antiviral, antitumor, and hepatoprotective properties. The antiviral activity of curcumin is establisheduding the human immunodeficiency virus (HI... See full list on The three compounds that were tested for their in vitro efficacy agauded aqueous turmeric root extract, a curcumin-containing nutritional supplement capsule, and curcumin (diferuloylmethane) from Sigma Aldrich. To obtain the root extract, the researchers reduced the turmeric root into fragments through a grater and centrifuged it to remove the solid components. They further purified the supernatant by ultracentrifugation. The nutritional capsule was dissolved in dimethyl sulfoxide (DMSO) and diluted in the culture medium for use. The researchers reported that one capsule contained 640 milligrams (mg) of turmeric powder, 105 mg turmeric extract (containing 99.9 mg curcumin), and 5 mg black pepper (containing 4.7 mg piperine). The curcumin alone was also dissolved and diluted similarly. The researchers have derived SARS-CoV-2 from an isolate obtained in a clinical nasopharyngeal swab of a patient with COVID-19 who was hospitalized in April 2020 at the... See full list on The researchers presented the cytopathic effects (CPE) using transmitted light microscopy. In this neutralization of SARS-CoV-2 by aqueous turmeric root extract, curcumin-containing nutritional supplement capsules, and curcumin, using various dilutions, the researchers calculated the concentration required for complete virus neutralization and calculated the EC50 values. For determining the dose-dependent antiviral activity, the researchers determined the EC50 of turmeric root extract was achieved at a dilution of 1:63.5. Comparatively, the EC50 values of the capsules and curcumin were achieved at a concentration of 7.4 micrograms (µg)/mL and 7.9 µg/mL, respectively. No cytotoxic effect was observed. Dose-dependent antiviral activity of aqueous turmeric root extract, curcumin-containing nutritional supplement capsules, and curcumin against SARS-CoV-2. Decreasing concentrations of aqueous turmeric root extract (1:8–1:1024 dilution) (A), nutritional supplement capsules (468.8–3.7 µg/m... See full list on Despite its low bioavailability and aqueous solubility issues, the results from this study highlight curcumin as a potent antiviral compound at low concentrations against SARS-CoV-2. The researchers demonstrated that the aqueous turmeric root extract, dissolved nutritional supplement capsules, as well as curcumin alone efficiently neutralized SARS-CoV-2 in Vero E6 and Calu-3 cell culture models. While results from undergoing clinical studies on the evaluation of benefits of curcumin the treatment of COVID-19 patients are pending, this study strongly demonstrates its activity against SARS-CoV-2 in vitro. The results discussed here to reaffirm that herbal medicines, which are cost-effective and easily available across the world, with antiviral activity are promising candidates for the complementary treatment of viral infections such as SARS-CoV-2 infections. See full list on
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