Use Most literature sources are from Japanese and Chinese foreign-language publications, clinical studies are on the efficacy of magnolia bark extract (MBE) are limited. Documentation on the materials and extracts for several studies is also limited. In vitro and animal studies document potential efficacy as an antibacterial, anti-inflammatory, and anticancer agent, as well as for use with Alzheimer disease, depression, diabetes, and menopause. Dosing MBE is commercially available in the United States and throughout Europe. Dosage varies depending on the condition treated, with weight loss products containing MBE available mostly in powder form. Several strengths are available for Relora, a patented blend marketed as "a natural stresudeude taking a 300 mg capsule of Relora 2 to 3 times per day. One small, randomized, controlled study treated patients with one 60 mg tablet... Contraindications Avoid use if hypersensitivity exists for any of the components in MBE. No absolute contraindication could be found in the medical literature. See full list on Numerous documented medicinal properties are associated with 2 major phenolic constituents, magnolol and honokiol, from the stem bark of M. officinalis Rehd. Et Wils.1, 2 Concentration variations of magnolol and honokiol exist in bas in China, as recorded in The Pharmacopoeia of the People's Republic of China. The plant is primarily indigenous to China and found at elevations of 200 to 3,000 meters.3 See full list on MBE has been used for over 1,000 years as a folk medicine in Asia.4, 5 In traditional Asian medicine, MBE has been prescribed for treating acute pain, headaches, diarrhea, allergies, asthma, and gynecological disorders. It has also been used to treat fever, anxiety, nervous disorders, depression, muscular pain, abdominal fullness, constipation, and thrombotic stroke.6, 7, 8, 9 In Chinese and Japanese folk medicine, MBE has been used to treat bronchitis and emphysema.10 See full list on Most literature sources are from Japanese and Chinese foreign-language publications, and clinical studies on the efficacy of magnolia bark extract are limited. Documentation on the materials and extracts for several studies is also limited. In vitro and animal studies document potential efficacy as an antibacterial, anti-inflammatory, and anticancer agent, as well as for use with Alzheimer disease, depression, diabetes, and menopause. See full list on MBE is commercially available in the United States and throughout Europe, as documented by Internet search engines. Dosage varies depending on the condition treated, with weight loss products containing MBE available mostly in powder form. Several strengths are available for Relora, a patented blend marketed as "a natural stresudeude taking a 300 mg capsule of Relora 2 to 3 times per day. A small, randomized, controlled study treated patients with one 60 mg tablet of MBE daily to help relieve menopausal symptoms.45 See full list on Avoid use during pregcy and lactation because of limited clinical data. An animal study documented that honokiol and magnolol blocked calcium-dependent uterine oscillatory contractions in rat uterus.5 See full list on Drug-herb interactions are documented, and caution is advisable in patients self-medicating with MBE. Magnolol may interact with acetaminophen one study documented reduced acetaminophen-induced liver damage in rats.6 Additive adverse reactions with antiplatelet medications may occur in patients also self-medicating with magnolol.57 MBE and honokiol may interact with benzodiazepines.8, 52 Magnolol may stimulate ease steroid medication concentrations.65MBE may cause excess sleepiness, vertigo, and dizziness in patients taking muscle relaxants. See full list on No adverse dermatologic effects were documented with topical application of magnolol and honokiol.14 In one small clinical trial, a patient dropped out because of auding heartburn, shaking hands, perilabial numbness, sexual dysfunction, and thyroid dysfunction.46 A few cases of allergic contact dermatitis have been reported in 4 patients who presenteuding vesicular, edematous, pruritic, scaly, and/or erythematous lesions after applying cosmetic creams containing M. officinalis bark extract. All patients’ hypersensitivity were validated with positive reactions to patch testing.72, 76 See full list on Dietary administration of MBE in rats at doses of up to 480 mg/kg in a 21-day study and 240 mg/kg in a 90-day study resulted in no clinically important toxi.7 Some sources document the development of progressive interstitial renal fibrosis in patients consuming an herbal blend containing M. officinalis.66, 67 In vitro studies demonstrate no genotoxic effects from MBE in chromosomal aberration assays.68 One study documented that magnolol in liver graft preservation enhanced apoptotic events under cold preservation instead of preserving hepatocyte integrity.69 See full list on This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information abude all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using th... See full list on
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